Acute viral hepatitis

Harmit Kalia, Paul Martin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Acute viral hepatitis is a systemic infection that affects predominantly the liver and remains a signifi cant cause of morbidity and mortality in the United States despite the availability of effective vaccination against hepatitis A and B, the two major causes of viral hepatitis. There are fi ve major hepatotropic viruses (A, B, C, D, and E) that cause acute hepatitis, resulting in acute hepatic necrosis and infl ammation. Acute viral hepatitis typically runs its course in 6 months or less, in contrast to chronic hepatitis, which persists for longer. However, with modern serological and molecular diagnostic testing, the time course is less important in distinguishing acute from chronic viral hepatitis. The clinical illness produced by these viruses can range from asymptomatic and clinically inapparent to a fulminant and fatal acute infection. A major distinction between hepatitis A and E compared to hepatitis B, C, and D is that the former cause acute hepatitis only in contrast to the latter three, which are also important causes of chronic hepatitis and cirrhosis. Other viral infections, such as Epstein–Barr virus (EBV) and cytomegalovirus (CMV), can present with prominent hepatic dysfunction, although they are usually multisystem disorders. Hepatitis G virus and TT virus (TTV) have also been implicated in causing hepatic dysfunction, but their clinical signifi cance remains dubious.

Original languageEnglish
Title of host publicationClinical Infectious Disease
PublisherCambridge University Press
Pages299-308
Number of pages10
ISBN (Print)9780511722240, 9780521871129
DOIs
StatePublished - Jan 1 2010

Fingerprint

Hepatitis
Chronic Hepatitis
Hepatitis A
Liver
Hepatitis B
Molecular Diagnostic Techniques
Torque teno virus
GB virus C
Hepatitis D
Hepatitis E
Viruses
Cercopithecine Herpesvirus 1
Virus Diseases
Hepatitis C
Infection
Cytomegalovirus
Vaccination
Fibrosis
Necrosis
Morbidity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kalia, H., & Martin, P. (2010). Acute viral hepatitis. In Clinical Infectious Disease (pp. 299-308). Cambridge University Press. https://doi.org/10.1017/CBO9780511722240.043

Acute viral hepatitis. / Kalia, Harmit; Martin, Paul.

Clinical Infectious Disease. Cambridge University Press, 2010. p. 299-308.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kalia, H & Martin, P 2010, Acute viral hepatitis. in Clinical Infectious Disease. Cambridge University Press, pp. 299-308. https://doi.org/10.1017/CBO9780511722240.043
Kalia H, Martin P. Acute viral hepatitis. In Clinical Infectious Disease. Cambridge University Press. 2010. p. 299-308 https://doi.org/10.1017/CBO9780511722240.043
Kalia, Harmit ; Martin, Paul. / Acute viral hepatitis. Clinical Infectious Disease. Cambridge University Press, 2010. pp. 299-308
@inbook{d66fa7fe870545fda526679ca129ea77,
title = "Acute viral hepatitis",
abstract = "Acute viral hepatitis is a systemic infection that affects predominantly the liver and remains a signifi cant cause of morbidity and mortality in the United States despite the availability of effective vaccination against hepatitis A and B, the two major causes of viral hepatitis. There are fi ve major hepatotropic viruses (A, B, C, D, and E) that cause acute hepatitis, resulting in acute hepatic necrosis and infl ammation. Acute viral hepatitis typically runs its course in 6 months or less, in contrast to chronic hepatitis, which persists for longer. However, with modern serological and molecular diagnostic testing, the time course is less important in distinguishing acute from chronic viral hepatitis. The clinical illness produced by these viruses can range from asymptomatic and clinically inapparent to a fulminant and fatal acute infection. A major distinction between hepatitis A and E compared to hepatitis B, C, and D is that the former cause acute hepatitis only in contrast to the latter three, which are also important causes of chronic hepatitis and cirrhosis. Other viral infections, such as Epstein–Barr virus (EBV) and cytomegalovirus (CMV), can present with prominent hepatic dysfunction, although they are usually multisystem disorders. Hepatitis G virus and TT virus (TTV) have also been implicated in causing hepatic dysfunction, but their clinical signifi cance remains dubious.",
author = "Harmit Kalia and Paul Martin",
year = "2010",
month = "1",
day = "1",
doi = "10.1017/CBO9780511722240.043",
language = "English",
isbn = "9780511722240",
pages = "299--308",
booktitle = "Clinical Infectious Disease",
publisher = "Cambridge University Press",

}

TY - CHAP

T1 - Acute viral hepatitis

AU - Kalia, Harmit

AU - Martin, Paul

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Acute viral hepatitis is a systemic infection that affects predominantly the liver and remains a signifi cant cause of morbidity and mortality in the United States despite the availability of effective vaccination against hepatitis A and B, the two major causes of viral hepatitis. There are fi ve major hepatotropic viruses (A, B, C, D, and E) that cause acute hepatitis, resulting in acute hepatic necrosis and infl ammation. Acute viral hepatitis typically runs its course in 6 months or less, in contrast to chronic hepatitis, which persists for longer. However, with modern serological and molecular diagnostic testing, the time course is less important in distinguishing acute from chronic viral hepatitis. The clinical illness produced by these viruses can range from asymptomatic and clinically inapparent to a fulminant and fatal acute infection. A major distinction between hepatitis A and E compared to hepatitis B, C, and D is that the former cause acute hepatitis only in contrast to the latter three, which are also important causes of chronic hepatitis and cirrhosis. Other viral infections, such as Epstein–Barr virus (EBV) and cytomegalovirus (CMV), can present with prominent hepatic dysfunction, although they are usually multisystem disorders. Hepatitis G virus and TT virus (TTV) have also been implicated in causing hepatic dysfunction, but their clinical signifi cance remains dubious.

AB - Acute viral hepatitis is a systemic infection that affects predominantly the liver and remains a signifi cant cause of morbidity and mortality in the United States despite the availability of effective vaccination against hepatitis A and B, the two major causes of viral hepatitis. There are fi ve major hepatotropic viruses (A, B, C, D, and E) that cause acute hepatitis, resulting in acute hepatic necrosis and infl ammation. Acute viral hepatitis typically runs its course in 6 months or less, in contrast to chronic hepatitis, which persists for longer. However, with modern serological and molecular diagnostic testing, the time course is less important in distinguishing acute from chronic viral hepatitis. The clinical illness produced by these viruses can range from asymptomatic and clinically inapparent to a fulminant and fatal acute infection. A major distinction between hepatitis A and E compared to hepatitis B, C, and D is that the former cause acute hepatitis only in contrast to the latter three, which are also important causes of chronic hepatitis and cirrhosis. Other viral infections, such as Epstein–Barr virus (EBV) and cytomegalovirus (CMV), can present with prominent hepatic dysfunction, although they are usually multisystem disorders. Hepatitis G virus and TT virus (TTV) have also been implicated in causing hepatic dysfunction, but their clinical signifi cance remains dubious.

UR - http://www.scopus.com/inward/record.url?scp=84923447773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923447773&partnerID=8YFLogxK

U2 - 10.1017/CBO9780511722240.043

DO - 10.1017/CBO9780511722240.043

M3 - Chapter

SN - 9780511722240

SN - 9780521871129

SP - 299

EP - 308

BT - Clinical Infectious Disease

PB - Cambridge University Press

ER -