Acute unilateral corneal immunoprotein deposition in IgM monoclonal gammopathy

Lee P. Schelonka, Gregory S.H. Ogawa, Terrence P. O'Brien, W. Richard Green

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


A healthy 43-year-old officer of a merchant ship at sea developed pain, redness, and photophobia in his right eye. During the next 2 weeks, he noted the presence of a band of opacity spreading from his temporal limbus toward his central cornea. His episcleral vessels were engorged in a distribution contiguous with the peripheral, sectorial, fleck-like corneal opacities. The opacity had progressed during topical and systemic antibiotic therapy, but halted with use of topical corticosteroids. Systemic evaluation showed mild IgM monoclonal gammopathy. Transmission electron microscopy of a corneal biopsy specimen revealed electron-dense fibrils identified as immunoprotein. To our knowledge, this is the first report of a case of acute unilateral deposition of corneal immunoprotein in a patient with monoclonal gammopathy. Clinicians should begin with a broad differential diagnosis when evaluating patients with corneal opacity.

Original languageEnglish (US)
Pages (from-to)125-126
Number of pages2
JournalArchives of ophthalmology
Issue number1
StatePublished - Jan 2000
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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