Acute Phase Protein Levels in Rabbits with Suspected Encephalitozoon cuniculi Infection

Carolyn Cray, Marilyn Rodriguez, Yaima Fernandez

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The objective of this study was to evaluate the application of acute phase protein assays for C-reactive protein (CRP), haptoglobin (HP), and serum amyloid A (SAA) in the diagnosis of Encephalitozoon cuniculi (ECUN) infection in pet rabbits. Serum samples from 48 pet rabbits were submitted from veterinary clinics within the United States. Participating veterinarians completed a questionnaire that was used to classify rabbits as either non-ECUN suspect (n = 19) or suspected of having ECUN infection (n = 29). A previously described enzyme-linked immunosorbent assay diagnostic test was used to detect immunoglobulin G (IgG) titers against ECUN. Samples were additionally tested for levels of CRP, HP, and SAA. A nearly 10-fold mean increase in CRP levels was observed in the ECUN-suspect group. This increase was significant (P < 0.05). There was no significant difference in HP or SAA levels between the clinical groups. These data support the use of CRP as an adjunct test in the diagnosis of ECUN infection in pet rabbits.

Original languageEnglish
Pages (from-to)280-286
Number of pages7
JournalJournal of Exotic Pet Medicine
Volume22
Issue number3
DOIs
StatePublished - Jul 1 2013

Fingerprint

Encephalitozoon cuniculi
acute phase proteins
Acute-Phase Proteins
C-reactive protein
Serum Amyloid A Protein
C-Reactive Protein
rabbits
Haptoglobins
haptoglobins
Rabbits
Pets
amyloid
pets
Infection
infection
Animal Hospitals
Veterinarians
immunoglobulin G
veterinary clinics
Protein C

Keywords

  • Acute phase protein
  • C-reactive protein
  • Encephalitozoon cuniculi
  • Haptoglobin
  • Protein electrophoresis
  • Serum amyloid A

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Acute Phase Protein Levels in Rabbits with Suspected Encephalitozoon cuniculi Infection. / Cray, Carolyn; Rodriguez, Marilyn; Fernandez, Yaima.

In: Journal of Exotic Pet Medicine, Vol. 22, No. 3, 01.07.2013, p. 280-286.

Research output: Contribution to journalArticle

Cray, Carolyn ; Rodriguez, Marilyn ; Fernandez, Yaima. / Acute Phase Protein Levels in Rabbits with Suspected Encephalitozoon cuniculi Infection. In: Journal of Exotic Pet Medicine. 2013 ; Vol. 22, No. 3. pp. 280-286.
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