Abstract
This paper reviews the results of an acute phase trial and a five-year follow-up study of fluoxetine in adolescents with major depression and a substance use disorder (SUD). This study included a 12-week open label acute phase study of 13 comorbid adolescents, followed by comprehensive assessments conducted 1, 3, and 5 years after entry into an acute phase fluoxetine trial. The results of the acute phase study and of the 1, 3, and 5-year follow-up assessments have already been published in four papers. The current paper was designed to cover the results of the study across the entire 5-year time spectrum of the study, and to summarize the clinical results across that entire time period. The data from this pilot study suggest that the long-term (5-year) clinical course for the Alcohol Dependence, Cannabis Dependence, and academic functioning of comorbid adolescents following acute phase treatment with SSRIs is generally good. However, the long-term clinical course for the Major Depression of that comorbid adolescent population is surprisingly poor.
Original language | English (US) |
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Pages (from-to) | 1824-1833 |
Number of pages | 10 |
Journal | Addictive Behaviors |
Volume | 30 |
Issue number | 9 |
DOIs | |
State | Published - Oct 2005 |
Externally published | Yes |
Keywords
- Adolescents
- Alcohol use disorder
- Fluoxetine
- Follow-up
- Major depression
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology