Abstract
This paper reviews the results of an acute phase trial and a five-year follow-up study of fluoxetine in adolescents with major depression and a substance use disorder (SUD). This study included a 12-week open label acute phase study of 13 comorbid adolescents, followed by comprehensive assessments conducted 1, 3, and 5 years after entry into an acute phase fluoxetine trial. The results of the acute phase study and of the 1, 3, and 5-year follow-up assessments have already been published in four papers. The current paper was designed to cover the results of the study across the entire 5-year time spectrum of the study, and to summarize the clinical results across that entire time period. The data from this pilot study suggest that the long-term (5-year) clinical course for the Alcohol Dependence, Cannabis Dependence, and academic functioning of comorbid adolescents following acute phase treatment with SSRIs is generally good. However, the long-term clinical course for the Major Depression of that comorbid adolescent population is surprisingly poor.
| Original language | English |
|---|---|
| Pages (from-to) | 1824-1833 |
| Number of pages | 10 |
| Journal | Addictive Behaviors |
| Volume | 30 |
| Issue number | 9 |
| DOIs | |
| State | Published - Oct 1 2005 |
| Externally published | Yes |
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Keywords
- Adolescents
- Alcohol use disorder
- Fluoxetine
- Follow-up
- Major depression
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Acute phase and five-year follow-up study of fluoxetine in adolescents with major depression and a comorbid substance use disorder : A review. / Cornelius, Jack R.; Clark, Duncan B.; Bukstein, Oscar G.; Birmaher, Boris; Salloum, Ihsan M; Brown, Sandra A.
In: Addictive Behaviors, Vol. 30, No. 9, 01.10.2005, p. 1824-1833.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute phase and five-year follow-up study of fluoxetine in adolescents with major depression and a comorbid substance use disorder
T2 - A review
AU - Cornelius, Jack R.
AU - Clark, Duncan B.
AU - Bukstein, Oscar G.
AU - Birmaher, Boris
AU - Salloum, Ihsan M
AU - Brown, Sandra A.
PY - 2005/10/1
Y1 - 2005/10/1
N2 - This paper reviews the results of an acute phase trial and a five-year follow-up study of fluoxetine in adolescents with major depression and a substance use disorder (SUD). This study included a 12-week open label acute phase study of 13 comorbid adolescents, followed by comprehensive assessments conducted 1, 3, and 5 years after entry into an acute phase fluoxetine trial. The results of the acute phase study and of the 1, 3, and 5-year follow-up assessments have already been published in four papers. The current paper was designed to cover the results of the study across the entire 5-year time spectrum of the study, and to summarize the clinical results across that entire time period. The data from this pilot study suggest that the long-term (5-year) clinical course for the Alcohol Dependence, Cannabis Dependence, and academic functioning of comorbid adolescents following acute phase treatment with SSRIs is generally good. However, the long-term clinical course for the Major Depression of that comorbid adolescent population is surprisingly poor.
AB - This paper reviews the results of an acute phase trial and a five-year follow-up study of fluoxetine in adolescents with major depression and a substance use disorder (SUD). This study included a 12-week open label acute phase study of 13 comorbid adolescents, followed by comprehensive assessments conducted 1, 3, and 5 years after entry into an acute phase fluoxetine trial. The results of the acute phase study and of the 1, 3, and 5-year follow-up assessments have already been published in four papers. The current paper was designed to cover the results of the study across the entire 5-year time spectrum of the study, and to summarize the clinical results across that entire time period. The data from this pilot study suggest that the long-term (5-year) clinical course for the Alcohol Dependence, Cannabis Dependence, and academic functioning of comorbid adolescents following acute phase treatment with SSRIs is generally good. However, the long-term clinical course for the Major Depression of that comorbid adolescent population is surprisingly poor.
KW - Adolescents
KW - Alcohol use disorder
KW - Fluoxetine
KW - Follow-up
KW - Major depression
UR - http://www.scopus.com/inward/record.url?scp=26644469521&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26644469521&partnerID=8YFLogxK
U2 - 10.1016/j.addbeh.2005.07.007
DO - 10.1016/j.addbeh.2005.07.007
M3 - Article
C2 - 16102905
AN - SCOPUS:26644469521
VL - 30
SP - 1824
EP - 1833
JO - Addictive Behaviors
JF - Addictive Behaviors
SN - 0306-4603
IS - 9
ER -