Acute phase and five-year follow-up study of fluoxetine in adolescents with major depression and a comorbid substance use disorder: A review

Jack R. Cornelius, Duncan B. Clark, Oscar G. Bukstein, Boris Birmaher, Ihsan M. Salloum, Sandra A. Brown

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

This paper reviews the results of an acute phase trial and a five-year follow-up study of fluoxetine in adolescents with major depression and a substance use disorder (SUD). This study included a 12-week open label acute phase study of 13 comorbid adolescents, followed by comprehensive assessments conducted 1, 3, and 5 years after entry into an acute phase fluoxetine trial. The results of the acute phase study and of the 1, 3, and 5-year follow-up assessments have already been published in four papers. The current paper was designed to cover the results of the study across the entire 5-year time spectrum of the study, and to summarize the clinical results across that entire time period. The data from this pilot study suggest that the long-term (5-year) clinical course for the Alcohol Dependence, Cannabis Dependence, and academic functioning of comorbid adolescents following acute phase treatment with SSRIs is generally good. However, the long-term clinical course for the Major Depression of that comorbid adolescent population is surprisingly poor.

Original languageEnglish (US)
Pages (from-to)1824-1833
Number of pages10
JournalAddictive Behaviors
Volume30
Issue number9
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

Keywords

  • Adolescents
  • Alcohol use disorder
  • Fluoxetine
  • Follow-up
  • Major depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

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