Abstract
Background. An epidemiological link between respiratory infection and acute myocardial infarction (AMI) has been suggested, and recent data indicate that there is an association between AMI and pneumococcal community-acquired pneumonia (CAP) in hospitalized patients. The objective of this study was to investigate the association of AMI with the severity of pneumonia at hospitalization and clinical failure during hospitalization among patients with CAP. Methods. An observational, retrospective study involving consecutive patients hospitalized with CAP was performed at the Veterans Hospital of Louisville, Kentucky. Patients admitted to the intensive care unit were defined as having severe CAP. Clinical failure was defined as the development of respiratory failure or shock. AMI was diagnosed on the basis of abnormal troponin levels and electrocardiogram findings. Propensity-adjusted models that controlled for clinical and nonclinical factors were used to investigate the association between AMI and pneumonia severity index and between AMI and clinical failure. Results. Data for a total of 500 patients were studied. At hospital admission, AMI was present in 13 (15%) of 86 patients with severe CAP. During hospitalization, AMI was present in 13 (20%) of 65 patients who experienced clinical failure. Following risk adjustment, significant associations were discovered between AMI and the pneumonia severity index score (modeled with a restricted cubic spline) (P = .05) and between AMI and clinical failure (P = .04). Conclusions. A combined diagnosis of CAP and AMI is common among hospitalized patients with severe CAP. In cases in which the clinical course of a hospitalized patient with CAP is complicated by clinical failure, AMI should be considered as a possible etiology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 182-187 |
| Number of pages | 6 |
| Journal | Clinical Infectious Diseases |
| Volume | 47 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 15 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Acute myocardial infarction in hospitalized patients with community-acquired pneumonia. / Ramirez, Julio; Aliberti, Stefano; Mirsaeidi, Mehdi; Peyrani, Paula; Filardo, Giovanni; Amir, Asad; Moffett, Bryan; Gordon, Josh; Blasi, Francesco; Bordon, Jose.
In: Clinical Infectious Diseases, Vol. 47, No. 2, 15.07.2008, p. 182-187.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute myocardial infarction in hospitalized patients with community-acquired pneumonia
AU - Ramirez, Julio
AU - Aliberti, Stefano
AU - Mirsaeidi, Mehdi
AU - Peyrani, Paula
AU - Filardo, Giovanni
AU - Amir, Asad
AU - Moffett, Bryan
AU - Gordon, Josh
AU - Blasi, Francesco
AU - Bordon, Jose
PY - 2008/7/15
Y1 - 2008/7/15
N2 - Background. An epidemiological link between respiratory infection and acute myocardial infarction (AMI) has been suggested, and recent data indicate that there is an association between AMI and pneumococcal community-acquired pneumonia (CAP) in hospitalized patients. The objective of this study was to investigate the association of AMI with the severity of pneumonia at hospitalization and clinical failure during hospitalization among patients with CAP. Methods. An observational, retrospective study involving consecutive patients hospitalized with CAP was performed at the Veterans Hospital of Louisville, Kentucky. Patients admitted to the intensive care unit were defined as having severe CAP. Clinical failure was defined as the development of respiratory failure or shock. AMI was diagnosed on the basis of abnormal troponin levels and electrocardiogram findings. Propensity-adjusted models that controlled for clinical and nonclinical factors were used to investigate the association between AMI and pneumonia severity index and between AMI and clinical failure. Results. Data for a total of 500 patients were studied. At hospital admission, AMI was present in 13 (15%) of 86 patients with severe CAP. During hospitalization, AMI was present in 13 (20%) of 65 patients who experienced clinical failure. Following risk adjustment, significant associations were discovered between AMI and the pneumonia severity index score (modeled with a restricted cubic spline) (P = .05) and between AMI and clinical failure (P = .04). Conclusions. A combined diagnosis of CAP and AMI is common among hospitalized patients with severe CAP. In cases in which the clinical course of a hospitalized patient with CAP is complicated by clinical failure, AMI should be considered as a possible etiology.
AB - Background. An epidemiological link between respiratory infection and acute myocardial infarction (AMI) has been suggested, and recent data indicate that there is an association between AMI and pneumococcal community-acquired pneumonia (CAP) in hospitalized patients. The objective of this study was to investigate the association of AMI with the severity of pneumonia at hospitalization and clinical failure during hospitalization among patients with CAP. Methods. An observational, retrospective study involving consecutive patients hospitalized with CAP was performed at the Veterans Hospital of Louisville, Kentucky. Patients admitted to the intensive care unit were defined as having severe CAP. Clinical failure was defined as the development of respiratory failure or shock. AMI was diagnosed on the basis of abnormal troponin levels and electrocardiogram findings. Propensity-adjusted models that controlled for clinical and nonclinical factors were used to investigate the association between AMI and pneumonia severity index and between AMI and clinical failure. Results. Data for a total of 500 patients were studied. At hospital admission, AMI was present in 13 (15%) of 86 patients with severe CAP. During hospitalization, AMI was present in 13 (20%) of 65 patients who experienced clinical failure. Following risk adjustment, significant associations were discovered between AMI and the pneumonia severity index score (modeled with a restricted cubic spline) (P = .05) and between AMI and clinical failure (P = .04). Conclusions. A combined diagnosis of CAP and AMI is common among hospitalized patients with severe CAP. In cases in which the clinical course of a hospitalized patient with CAP is complicated by clinical failure, AMI should be considered as a possible etiology.
UR - http://www.scopus.com/inward/record.url?scp=46349099104&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46349099104&partnerID=8YFLogxK
U2 - 10.1086/589246
DO - 10.1086/589246
M3 - Article
C2 - 18533841
AN - SCOPUS:46349099104
VL - 47
SP - 182
EP - 187
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 2
ER -