Acute myeloid leukemia presenting with panhypopituitarism or diabetes insipidus: A case series with molecular genetic analysis and review of the literature

Elizabeth H. Cull, Justin M. Watts, Martin S. Tallman, Peter Kopp, Mark Frattini, Franck Rapaport, Raajit Rampal, Ross Levine, Jessica K. Altman

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Central diabetes insipidus (DI) is a rare finding in patients with acute myeloid leukemia (AML), usually occurring in patients with chromosome 3 or 7 abnormalities. We describe four patients with AML and concurrent DI and a fifth patient with AML and panhypopituitarism. Four of five patients had monosomy 7. Three patients had chromosome 3q21q26/EVI-1 gene rearrangements. The molecular genotype of patients with AML and DI is not known. Therefore, we performed gene sequencing of 30 genes commonly mutated in AML in three patients with available leukemia cell DNA. One patient had no identifiable mutations, and two had RUNX1 F158S mutations.

Original languageEnglish (US)
Pages (from-to)2125-2129
Number of pages5
JournalLeukemia and Lymphoma
Volume55
Issue number9
DOIs
StatePublished - Sep 2014
Externally publishedYes

Keywords

  • Acute myeloid leukemia
  • Diabetes insipidus
  • Panhypopituitarism

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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