Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells

Josephine Wesely, Andriana G. Kotini, Franco Izzo, Hanzhi Luo, Han Yuan, Jun Sun, Maria Georgomanoli, Asaf Zviran, André G. Deslauriers, Neville Dusaj, Stephen D. Nimer, Christina Leslie, Dan A. Landau, Michael G. Kharas, Eirini P. Papapetrou

Research output: Contribution to journalArticlepeer-review

Abstract

Wesely et al. report that AML-iPSC-derived hematopoietic cells are hierarchically organized and contain cells with hallmark features of LSCs (iLSCs). Through integrative genomic studies of bulk and single-cell transcriptomes and chromatin accessibility, they derive a LSC gene signature and identify RUNX1 as an AML LSC dependency with therapeutic implications.

Original languageEnglish (US)
Article number107688
JournalCell Reports
Volume31
Issue number9
DOIs
StatePublished - Jun 2 2020

Keywords

  • AML
  • LSC gene signature
  • Leukemia stem cells
  • RUNX1
  • iLSCs
  • iPSCs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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