Acute monoblastic leukemia in two infants: Clinical, histochemical, and immunologic investigations

R. Beverly Raney, T. Mohanakumar, Richard S. Metzgar, Hie Won L. Hann, Billy E. Buck, Milton H. Donaldson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Two infant girls developed acute non-lymphocytic leukemia. One had previously had cutaneous nodules diagnosed as a malignancy of the reticulo-endothelial system. The purpose of this work was to characterize the malignant cells and to summarize the response to treatment. Malignant cells from both patients resembled monoblasts morphologically, and the esterase staining pattern suggested monocytic differentiation. Leukemic cells from one patient were capable of phagocytosis. Immunoglobulin G was detected on the surface membranes of the malignant cells of both patients. Blast cells from both patients were examined repeatedly for the presence of leukemia-associated antigens, using various antisera to human leukemia cells, and the reactivity pattern was similar to that of blasts from other patients with acute myelomonocytic leukemia. The evolution of the disease and rapid clinical course in both infants was consistent with the diagnosis of acute monoblastic leukemia. Because of its poor prognosis, this disorder should be distinguished from the more common varieties of childhood acute leukemia.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalLeukemia Research
Issue number1
StatePublished - 1980


  • Acute monoblastic leukemia
  • childhood

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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