Acute monoblastic leukemia in two infants: Clinical, histochemical, and immunologic investigations

R. Beverly Raney, T. Mohanakumar, Richard S. Metzgar, Hie Won L Hann, Billy E. Buck, Milton H. Donaldson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Two infant girls developed acute non-lymphocytic leukemia. One had previously had cutaneous nodules diagnosed as a malignancy of the reticulo-endothelial system. The purpose of this work was to characterize the malignant cells and to summarize the response to treatment. Malignant cells from both patients resembled monoblasts morphologically, and the esterase staining pattern suggested monocytic differentiation. Leukemic cells from one patient were capable of phagocytosis. Immunoglobulin G was detected on the surface membranes of the malignant cells of both patients. Blast cells from both patients were examined repeatedly for the presence of leukemia-associated antigens, using various antisera to human leukemia cells, and the reactivity pattern was similar to that of blasts from other patients with acute myelomonocytic leukemia. The evolution of the disease and rapid clinical course in both infants was consistent with the diagnosis of acute monoblastic leukemia. Because of its poor prognosis, this disorder should be distinguished from the more common varieties of childhood acute leukemia.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalLeukemia Research
Volume4
Issue number1
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

Fingerprint

Leukemia, Monocytic, Acute
Leukemia
Monocyte-Macrophage Precursor Cells
Leukemia, Myelomonocytic, Acute
Esterases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Phagocytosis
Immune Sera
Immunoglobulin G
Cell Membrane
Staining and Labeling
Antigens
Skin
Neoplasms

Keywords

  • Acute monoblastic leukemia
  • childhood

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Raney, R. B., Mohanakumar, T., Metzgar, R. S., Hann, H. W. L., Buck, B. E., & Donaldson, M. H. (1980). Acute monoblastic leukemia in two infants: Clinical, histochemical, and immunologic investigations. Leukemia Research, 4(1), 61-67. https://doi.org/10.1016/0145-2126(80)90046-6

Acute monoblastic leukemia in two infants : Clinical, histochemical, and immunologic investigations. / Raney, R. Beverly; Mohanakumar, T.; Metzgar, Richard S.; Hann, Hie Won L; Buck, Billy E.; Donaldson, Milton H.

In: Leukemia Research, Vol. 4, No. 1, 01.01.1980, p. 61-67.

Research output: Contribution to journalArticle

Raney, RB, Mohanakumar, T, Metzgar, RS, Hann, HWL, Buck, BE & Donaldson, MH 1980, 'Acute monoblastic leukemia in two infants: Clinical, histochemical, and immunologic investigations', Leukemia Research, vol. 4, no. 1, pp. 61-67. https://doi.org/10.1016/0145-2126(80)90046-6
Raney, R. Beverly ; Mohanakumar, T. ; Metzgar, Richard S. ; Hann, Hie Won L ; Buck, Billy E. ; Donaldson, Milton H. / Acute monoblastic leukemia in two infants : Clinical, histochemical, and immunologic investigations. In: Leukemia Research. 1980 ; Vol. 4, No. 1. pp. 61-67.
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