Acute macular neuroretinopathy in dengue virus serotype 1

Gabriel A. Guardiola, Victor M. Villegas, Vanessa Cruz-Villegas, Stephen G. Schwartz

Research output: Contribution to journalArticlepeer-review


Purpose: To report a case of acute macular neuroretinopathy (AMN) associated with dengue virus serotype 1 infection. Observation: An 18-year-old Puerto Rican female was evaluated due to painless paracentral scotomas in each eye that developed after being hospitalized for dengue fever a week before. Clinical examination and multimodal imaging revealed bilateral hypopigmented macular lesions, hyperreflectivity at the outer nuclear and photoreceptor layer, and reduced flow signal in the deep capillary plexus. Additionally, hypoautofluorescent parafoveal lesions were found in the left eye. AMN was diagnosed. Two-month follow-up after the initial evaluation showed resolution of symptoms but persistence of some findings on optical coherence tomography. Conclusions and importance: Patients with dengue virus serotype 1 may develop paracentral scotomas with classic AMN findings and obtain complete symptomatic recovery without treatment.

Original languageEnglish (US)
Article number101250
JournalAmerican Journal of Ophthalmology Case Reports
StatePublished - Mar 2022
Externally publishedYes


  • Acute macular neuroretinopathy
  • Dengue fever
  • Dengue maculopathy

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Acute macular neuroretinopathy in dengue virus serotype 1'. Together they form a unique fingerprint.

Cite this