Acute lymphoblastic leukemia presenting in fulminant hepatic failure

Jason B. Litten, Maria M. Rodríguez, Vincenzo Maniaci

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


A previously healthy 4-year-old boy was admitted because of acute liver failure. He was icteric, lethargic, had elevated ammonia and abnormal liver function tests. Serology was negative for viral hepatitis. There was no history of hepatotoxic drugs. Family history was unremarkable. The child was taken to the operating room for a living-related hepatic transplant. Frozen section showed massive hepatic leukemic infiltration and hepatocellular necrosis. Bone marrow aspiration confirmed the diagnosis of acute lymphoblastic leukemia (ALL). Transplant was withheld and chemotherapy was attempted. He died the following day due to systemic leukemic infiltration, cerebral edema, and severe anoxic ischemic encephalopathy.

Original languageEnglish (US)
Pages (from-to)842-845
Number of pages4
JournalPediatric Blood and Cancer
Issue number6
StatePublished - Nov 2006


  • ALL
  • Cerebral edema
  • Hepatic encephalopathy
  • Leukemia
  • Liver failure
  • Malignancy

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology


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