Acute hyperammonemia in the young primate: Physiologic and neuropathologic correlates

T. M. Voorhies, M. E. Ehrlich, T. E. Duffy, Carol Petito, F. Plum

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Infusion-induced acute (≤ 24 h) hyperammonemia to concentrations up to five times normal (0.19 ± 0.03 versus 0.90 ± 0.08 mM) was studied in eleven 6-9-month-old Macaca mullata. The young primates developed a progressive reduction of consciousness that correlated in severity directly with the elevation of blood ammonia concentration. Hyperventilation, electroencephalographic slowing, occasional seizure activity, and, eventually, apneustic breathing also occurred. Intracranial pressure rose from 76 ± 7 to 167 ± 12 mmH2O. Arterial oxygen and blood pressure remained within normal limits. Neuropathologic examination showed early astrocytic changes, consisting primarily of swollen perikaryal cytoplasm and processes, and membranous whorls. The absence of neuronal pathology suggests that the acute, limited insult, as occurs in many of the childhood hyperammonemic syndromes, is fully reversible.

Original languageEnglish
Pages (from-to)970-975
Number of pages6
JournalPediatric Research
Volume17
Issue number12
StatePublished - Dec 1 1983
Externally publishedYes

Fingerprint

Hyperammonemia
Hyperventilation
Intracranial Pressure
Macaca
Consciousness
Ammonia
Primates
Arterial Pressure
Respiration
Cytoplasm
Seizures
Pathology
Oxygen

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Voorhies, T. M., Ehrlich, M. E., Duffy, T. E., Petito, C., & Plum, F. (1983). Acute hyperammonemia in the young primate: Physiologic and neuropathologic correlates. Pediatric Research, 17(12), 970-975.

Acute hyperammonemia in the young primate : Physiologic and neuropathologic correlates. / Voorhies, T. M.; Ehrlich, M. E.; Duffy, T. E.; Petito, Carol; Plum, F.

In: Pediatric Research, Vol. 17, No. 12, 01.12.1983, p. 970-975.

Research output: Contribution to journalArticle

Voorhies, TM, Ehrlich, ME, Duffy, TE, Petito, C & Plum, F 1983, 'Acute hyperammonemia in the young primate: Physiologic and neuropathologic correlates', Pediatric Research, vol. 17, no. 12, pp. 970-975.
Voorhies TM, Ehrlich ME, Duffy TE, Petito C, Plum F. Acute hyperammonemia in the young primate: Physiologic and neuropathologic correlates. Pediatric Research. 1983 Dec 1;17(12):970-975.
Voorhies, T. M. ; Ehrlich, M. E. ; Duffy, T. E. ; Petito, Carol ; Plum, F. / Acute hyperammonemia in the young primate : Physiologic and neuropathologic correlates. In: Pediatric Research. 1983 ; Vol. 17, No. 12. pp. 970-975.
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