Acute HIV infection with rapid progression to AIDS

Marcio de Oliveira Silva, Milena Bastos, Eduardo Martins Netto, Nancy Alves de Lima Gouvea, Alex Jose Leite Torres, Esper Kallas, David I. Watkins, Marcus Altfeld, Carlos Brites

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm3 within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm3 and 10 months to HIV-RNA to become undetectable.

Original languageEnglish (US)
Pages (from-to)291-293
Number of pages3
JournalBrazilian Journal of Infectious Diseases
Volume14
Issue number3
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Keywords

  • Acute infection
  • AIDS
  • HIV
  • Progression

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    de Oliveira Silva, M., Bastos, M., Netto, E. M., de Lima Gouvea, N. A., Torres, A. J. L., Kallas, E., Watkins, D. I., Altfeld, M., & Brites, C. (2010). Acute HIV infection with rapid progression to AIDS. Brazilian Journal of Infectious Diseases, 14(3), 291-293. https://doi.org/10.1016/S1413-8670(10)70059-3