TY - JOUR
T1 - Acute HIV infection with rapid progression to AIDS
AU - de Oliveira Silva, Marcio
AU - Bastos, Milena
AU - Netto, Eduardo Martins
AU - de Lima Gouvea, Nancy Alves
AU - Torres, Alex Jose Leite
AU - Kallas, Esper
AU - Watkins, David I.
AU - Altfeld, Marcus
AU - Brites, Carlos
PY - 2010
Y1 - 2010
N2 - Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm3 within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm3 and 10 months to HIV-RNA to become undetectable.
AB - Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm3 within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm3 and 10 months to HIV-RNA to become undetectable.
KW - Acute infection
KW - AIDS
KW - HIV
KW - Progression
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U2 - 10.1016/S1413-8670(10)70059-3
DO - 10.1016/S1413-8670(10)70059-3
M3 - Article
C2 - 20835515
AN - SCOPUS:77957934940
VL - 14
SP - 291
EP - 293
JO - Brazilian Journal of Infectious Diseases
JF - Brazilian Journal of Infectious Diseases
SN - 1413-8670
IS - 3
ER -
