Acute graft-versus-host disease (aGVHD) presenting with an acquired lupus anticoagulant

M. A. Kharfan-Dabaja, D. Morgensztern, E. Santos, Mark Goodman, H. F. Fernandez

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

There are few reports describing the association between antiphospholipid antibodies, including the lupus anticoagulant, and bone marrow or peripheral stem cell transplantation. Autoimmune syndromes and autoantibodies such as lupus anticoagulant and anticardiolipin antibodies have been described following allogeneic bone marrow or peripheral blood stem cell transplantation, particularly in patients who develop chronic graft-versus-host disease (GVHD). The association between Lupus anticoagulant and acute GVHD has not been previously described. We report a patient who developed a de novo lupus anticoagulant on day + 34 after a matched-related allogeneic peripheral stem cell transplant. No clinical evidence of systemic thrombosis was observed and the lupus anticoagulant disappeared following immunosuppressive therapy with a combination of steroids and infliximab.

Original languageEnglish
Pages (from-to)129-131
Number of pages3
JournalBone Marrow Transplantation
Volume31
Issue number2
DOIs
StatePublished - Jan 1 2003

Fingerprint

Lupus Coagulation Inhibitor
Graft vs Host Disease
Peripheral Blood Stem Cell Transplantation
Bone Marrow
Anticardiolipin Antibodies
Antiphospholipid Antibodies
Immunosuppressive Agents
Autoantibodies
Thrombosis
Steroids
Transplants

Keywords

  • Acute GVHD
  • Bone marrow transplantation
  • Lupus anticoagulant
  • Peripheral stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Acute graft-versus-host disease (aGVHD) presenting with an acquired lupus anticoagulant. / Kharfan-Dabaja, M. A.; Morgensztern, D.; Santos, E.; Goodman, Mark; Fernandez, H. F.

In: Bone Marrow Transplantation, Vol. 31, No. 2, 01.01.2003, p. 129-131.

Research output: Contribution to journalArticle

Kharfan-Dabaja, M. A. ; Morgensztern, D. ; Santos, E. ; Goodman, Mark ; Fernandez, H. F. / Acute graft-versus-host disease (aGVHD) presenting with an acquired lupus anticoagulant. In: Bone Marrow Transplantation. 2003 ; Vol. 31, No. 2. pp. 129-131.
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