Acute graft-versus-host disease (aGVHD) presenting with an acquired lupus anticoagulant

M. A. Kharfan-Dabaja, D. Morgensztern, E. Santos, M. Goodman, H. F. Fernandez

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

There are few reports describing the association between antiphospholipid antibodies, including the lupus anticoagulant, and bone marrow or peripheral stem cell transplantation. Autoimmune syndromes and autoantibodies such as lupus anticoagulant and anticardiolipin antibodies have been described following allogeneic bone marrow or peripheral blood stem cell transplantation, particularly in patients who develop chronic graft-versus-host disease (GVHD). The association between Lupus anticoagulant and acute GVHD has not been previously described. We report a patient who developed a de novo lupus anticoagulant on day + 34 after a matched-related allogeneic peripheral stem cell transplant. No clinical evidence of systemic thrombosis was observed and the lupus anticoagulant disappeared following immunosuppressive therapy with a combination of steroids and infliximab.

Original languageEnglish (US)
Pages (from-to)129-131
Number of pages3
JournalBone Marrow Transplantation
Volume31
Issue number2
DOIs
StatePublished - Jan 1 2003

Keywords

  • Acute GVHD
  • Bone marrow transplantation
  • Lupus anticoagulant
  • Peripheral stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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