Acute glucose loads in insulinized pancreatectomized dogs

C. Abraira, M. S. Goldstein

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Pancreatectomized dogs maintained in a steady-state of glucose utilization by the constant infusion of saline-insulin-glucose were studied. Measurements of glucose and immunoreactive insulin (IRI) in blood and lymph were performed before and after acute glucose loads and the results compared with those obtained from similarly treated normal dogs. Both animal groups utilized acute glucose loads in similar fashion. The normal dogs had higher pre- and postload IRI levels than those of the pancreatectomized animals. It is concluded that in the presence of stable, insulin-mediated, glucose utilization normal tolerance to an intravenous glucose load can occur without, and independent of, an increase in insulin concentration.

Original languageEnglish (US)
Pages (from-to)696-703
Number of pages8
JournalThe Journal of Laboratory and Clinical Medicine
Volume81
Issue number5
StatePublished - May 1973

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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