TY - JOUR
T1 - Acute generalised exanthematous pustulosis associated with shock
AU - Costa, Philippos Apolinario
AU - Costa, Bruna Menon Loureiro Apolinario
AU - Milikowski, Clara
AU - St Onge, Joan E.
N1 - Publisher Copyright:
© 2020 BMJ Publishing Group. All rights reserved.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/10/30
Y1 - 2020/10/30
N2 - A 23-year-old man with a history of end-stage renal disease was admitted to the hospital due to fever and shock, which occurred during his dialysis. One week prior, he developed an erythematous rash on his chest, face and back, associated with generalised eruption of pustules. In hospital, his status did not improve with norepinephrine and empirical broad-spectrum antibiotics. Following this, methylprednisolone was administered with remarkable improvement. Cultures revealed no infectious aetiology. Based on the morphology of the rash and a compatible skin biopsy, the diagnosis of acute generalised exanthematous pustulosis (AGEP) was established and considered the cause of his shock. The causative agent of his AGEP remained unknown. AGEP is a rare condition, most frequently associated with drug exposure. The removal of the offending agent is the treatment of choice. It can be complicated by shock in rare cases. In that scenario, systemic corticosteroids seem to improve outcomes greatly.
AB - A 23-year-old man with a history of end-stage renal disease was admitted to the hospital due to fever and shock, which occurred during his dialysis. One week prior, he developed an erythematous rash on his chest, face and back, associated with generalised eruption of pustules. In hospital, his status did not improve with norepinephrine and empirical broad-spectrum antibiotics. Following this, methylprednisolone was administered with remarkable improvement. Cultures revealed no infectious aetiology. Based on the morphology of the rash and a compatible skin biopsy, the diagnosis of acute generalised exanthematous pustulosis (AGEP) was established and considered the cause of his shock. The causative agent of his AGEP remained unknown. AGEP is a rare condition, most frequently associated with drug exposure. The removal of the offending agent is the treatment of choice. It can be complicated by shock in rare cases. In that scenario, systemic corticosteroids seem to improve outcomes greatly.
KW - drugs and medicines
KW - skin
KW - unwanted effects / adverse reactions
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U2 - 10.1136/bcr-2020-235846
DO - 10.1136/bcr-2020-235846
M3 - Article
C2 - 33127730
AN - SCOPUS:85095399964
VL - 13
JO - BMJ Case Reports
JF - BMJ Case Reports
SN - 1757-790X
IS - 10
M1 - e235846
ER -