Acute effects of sildenafil (viagra) on blue-on-yellow and white-on-white Humphrey perimetry

T. J. McCulley, Byron L Lam, M. F. Marmor, K. B. Hoffman, J. K. Luu, William J Feuer

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: To study the effects of sildenafil on blue-on-yellow and white-on-white Humphrey visual field (HVF). Materials and Methods: Healthy subjects, ages 20 to 38 years, were prospectively randomized to active drug (n = 5) or placebo (n = 3) groups. Blue-on-yellow and white-on-white HVF testing was performed before and I hour after masked dosing of sildenafil 200 mg or placebo. Changes in mean deviation (MD) were compared between groups. Results: Three of three placebo and four of five sildenafil subjects had no change on HVF. One of five sildenafil subjects had a decrease in MD of 17.9 dB and 4.7 dB on blue-on-yellow and white-on-white HVF testing, respectively. This subject reported more systemic side effects than other subjects. Conclusions: Sildenafil has no effect on HVF testing in most persons; however, sildenafil caused an acute abnormality of HVF testing in one subject, who experienced pronounced nonvisual systemic symptoms; this effect was greater on blue-on-yellow than white-on-white HVF.

Original languageEnglish
Pages (from-to)227-228
Number of pages2
JournalJournal of Neuro-Ophthalmology
Volume20
Issue number4
StatePublished - Dec 21 2000
Externally publishedYes

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Visual Field Tests
Visual Fields
Placebos
Sildenafil Citrate
Healthy Volunteers
Pharmaceutical Preparations

Keywords

  • Humphrey visual field
  • Ophthalmology
  • Side effects
  • Sildenafil
  • Viagra

ASJC Scopus subject areas

  • Clinical Neurology
  • Ophthalmology

Cite this

McCulley, T. J., Lam, B. L., Marmor, M. F., Hoffman, K. B., Luu, J. K., & Feuer, W. J. (2000). Acute effects of sildenafil (viagra) on blue-on-yellow and white-on-white Humphrey perimetry. Journal of Neuro-Ophthalmology, 20(4), 227-228.

Acute effects of sildenafil (viagra) on blue-on-yellow and white-on-white Humphrey perimetry. / McCulley, T. J.; Lam, Byron L; Marmor, M. F.; Hoffman, K. B.; Luu, J. K.; Feuer, William J.

In: Journal of Neuro-Ophthalmology, Vol. 20, No. 4, 21.12.2000, p. 227-228.

Research output: Contribution to journalArticle

McCulley, TJ, Lam, BL, Marmor, MF, Hoffman, KB, Luu, JK & Feuer, WJ 2000, 'Acute effects of sildenafil (viagra) on blue-on-yellow and white-on-white Humphrey perimetry', Journal of Neuro-Ophthalmology, vol. 20, no. 4, pp. 227-228.
McCulley, T. J. ; Lam, Byron L ; Marmor, M. F. ; Hoffman, K. B. ; Luu, J. K. ; Feuer, William J. / Acute effects of sildenafil (viagra) on blue-on-yellow and white-on-white Humphrey perimetry. In: Journal of Neuro-Ophthalmology. 2000 ; Vol. 20, No. 4. pp. 227-228.
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