Acute effects of oral ethacrynic acid upon total blood volume

Philip Samet; William H. Bernstein

doi:10.1016/0002-8703(68)90084-7

Acute effects of oral ethacrynic acid upon total blood volume

Philip Samet, William H. Bernstein

Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The acute effects of oral ethacrynic acid administration upon red cell mass and plasma volume are reported in 30 patients. A significant decrease in plasma volume has been observed and is in all probability secondary to the profound diuretic effect of the drug, unlike the transient effect of phlebotomy which is largely gone by one hour. The effect of ethacrynic acid in lowering the plasma volume persists for at least 2 to 3 hours. The therapeutic implications for the patient with pulmonary edema are readily evident.

Original language	English (US)
Pages (from-to)	288-290
Number of pages	3
Journal	American Heart Journal
Volume	75
Issue number	3
DOIs	https://doi.org/10.1016/0002-8703(68)90084-7
State	Published - Mar 1968

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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title = "Acute effects of oral ethacrynic acid upon total blood volume",

abstract = "The acute effects of oral ethacrynic acid administration upon red cell mass and plasma volume are reported in 30 patients. A significant decrease in plasma volume has been observed and is in all probability secondary to the profound diuretic effect of the drug, unlike the transient effect of phlebotomy which is largely gone by one hour. The effect of ethacrynic acid in lowering the plasma volume persists for at least 2 to 3 hours. The therapeutic implications for the patient with pulmonary edema are readily evident.",

author = "Philip Samet and Bernstein, {William H.}",

note = "Funding Information: From the Section of Cardiology, Department of Medicine, 1LIt. Sinai Hospital, Miami School of Medicine, Coral Gables. Fla. Supported by research grants from the National Heart Institute HE-09782.02 Received for publication Feb. 16, 1967.",

year = "1968",

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AU - Bernstein, William H.

N1 - Funding Information: From the Section of Cardiology, Department of Medicine, 1LIt. Sinai Hospital, Miami School of Medicine, Coral Gables. Fla. Supported by research grants from the National Heart Institute HE-09782.02 Received for publication Feb. 16, 1967.

PY - 1968/3

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N2 - The acute effects of oral ethacrynic acid administration upon red cell mass and plasma volume are reported in 30 patients. A significant decrease in plasma volume has been observed and is in all probability secondary to the profound diuretic effect of the drug, unlike the transient effect of phlebotomy which is largely gone by one hour. The effect of ethacrynic acid in lowering the plasma volume persists for at least 2 to 3 hours. The therapeutic implications for the patient with pulmonary edema are readily evident.

AB - The acute effects of oral ethacrynic acid administration upon red cell mass and plasma volume are reported in 30 patients. A significant decrease in plasma volume has been observed and is in all probability secondary to the profound diuretic effect of the drug, unlike the transient effect of phlebotomy which is largely gone by one hour. The effect of ethacrynic acid in lowering the plasma volume persists for at least 2 to 3 hours. The therapeutic implications for the patient with pulmonary edema are readily evident.

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Acute effects of oral ethacrynic acid upon total blood volume

Abstract

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