TY - JOUR
T1 - Acute effects of oral ethacrynic acid upon total blood volume
AU - Samet, Philip
AU - Bernstein, William H.
PY - 1968/3
Y1 - 1968/3
N2 - The acute effects of oral ethacrynic acid administration upon red cell mass and plasma volume are reported in 30 patients. A significant decrease in plasma volume has been observed and is in all probability secondary to the profound diuretic effect of the drug, unlike the transient effect of phlebotomy which is largely gone by one hour. The effect of ethacrynic acid in lowering the plasma volume persists for at least 2 to 3 hours. The therapeutic implications for the patient with pulmonary edema are readily evident.
AB - The acute effects of oral ethacrynic acid administration upon red cell mass and plasma volume are reported in 30 patients. A significant decrease in plasma volume has been observed and is in all probability secondary to the profound diuretic effect of the drug, unlike the transient effect of phlebotomy which is largely gone by one hour. The effect of ethacrynic acid in lowering the plasma volume persists for at least 2 to 3 hours. The therapeutic implications for the patient with pulmonary edema are readily evident.
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U2 - 10.1016/0002-8703(68)90084-7
DO - 10.1016/0002-8703(68)90084-7
M3 - Article
C2 - 5638467
AN - SCOPUS:0014258771
VL - 75
SP - 288
EP - 290
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 3
ER -