Abstract
Cigarette smoke contains irritants and vasoactive substances. We wanted to determine the effect of smoking a cigarette and of nasally or orally inhaled nicotine on airway blood flow (Qaw) and airflow in smokers. In ten healthy current smokers, Qaw, FEV1, and FEF 25-75 were measured before and at 5, 30, and 180 min after smoking a cigarette. The effects of systemic nicotine using a nicotine nasal spray and local nicotine using a nicotine inhaler were also studied. Mean (± SE) Qaw increased by 81% ± 16% (p = 0.03) 5 min after smoking a cigarette and was no longer different from baseline at 30 and 180 min. Nicotine nasal spray and nicotine oral inhaler had no effect on Qaw. FEV 1 and FEF25-75 remained unchanged after smoking a cigarette and after local or systemic nicotine administration. Smoking a cigarette is followed by a transient increase in airway blood flow but no changes in airflow. Nicotine, at the rate and dose provided by the nasal spray (systemic action) and oral inhaler (local and systemic action), does not appear to be involved in the Qaw change, suggesting a pharmacologic or nonspecific irritant effect of other cigarette smoke constituents.
| Original language | English |
|---|---|
| Pages (from-to) | 363-368 |
| Number of pages | 6 |
| Journal | Lung |
| Volume | 184 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2006 |
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Keywords
- Airway blood flow
- Cigarette smoking
- Spirometry and nicotine
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Physiology
Cite this
Acute effect of cigarette smoke and nicotine on airway blood flow and airflow in healthy smokers. / Randhawa, Kanwaldeep; Mendes, Eliana; Wanner, Adam.
In: Lung, Vol. 184, No. 6, 01.12.2006, p. 363-368.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute effect of cigarette smoke and nicotine on airway blood flow and airflow in healthy smokers
AU - Randhawa, Kanwaldeep
AU - Mendes, Eliana
AU - Wanner, Adam
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Cigarette smoke contains irritants and vasoactive substances. We wanted to determine the effect of smoking a cigarette and of nasally or orally inhaled nicotine on airway blood flow (Qaw) and airflow in smokers. In ten healthy current smokers, Qaw, FEV1, and FEF 25-75 were measured before and at 5, 30, and 180 min after smoking a cigarette. The effects of systemic nicotine using a nicotine nasal spray and local nicotine using a nicotine inhaler were also studied. Mean (± SE) Qaw increased by 81% ± 16% (p = 0.03) 5 min after smoking a cigarette and was no longer different from baseline at 30 and 180 min. Nicotine nasal spray and nicotine oral inhaler had no effect on Qaw. FEV 1 and FEF25-75 remained unchanged after smoking a cigarette and after local or systemic nicotine administration. Smoking a cigarette is followed by a transient increase in airway blood flow but no changes in airflow. Nicotine, at the rate and dose provided by the nasal spray (systemic action) and oral inhaler (local and systemic action), does not appear to be involved in the Qaw change, suggesting a pharmacologic or nonspecific irritant effect of other cigarette smoke constituents.
AB - Cigarette smoke contains irritants and vasoactive substances. We wanted to determine the effect of smoking a cigarette and of nasally or orally inhaled nicotine on airway blood flow (Qaw) and airflow in smokers. In ten healthy current smokers, Qaw, FEV1, and FEF 25-75 were measured before and at 5, 30, and 180 min after smoking a cigarette. The effects of systemic nicotine using a nicotine nasal spray and local nicotine using a nicotine inhaler were also studied. Mean (± SE) Qaw increased by 81% ± 16% (p = 0.03) 5 min after smoking a cigarette and was no longer different from baseline at 30 and 180 min. Nicotine nasal spray and nicotine oral inhaler had no effect on Qaw. FEV 1 and FEF25-75 remained unchanged after smoking a cigarette and after local or systemic nicotine administration. Smoking a cigarette is followed by a transient increase in airway blood flow but no changes in airflow. Nicotine, at the rate and dose provided by the nasal spray (systemic action) and oral inhaler (local and systemic action), does not appear to be involved in the Qaw change, suggesting a pharmacologic or nonspecific irritant effect of other cigarette smoke constituents.
KW - Airway blood flow
KW - Cigarette smoking
KW - Spirometry and nicotine
UR - http://www.scopus.com/inward/record.url?scp=33845426714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845426714&partnerID=8YFLogxK
U2 - 10.1007/s00408-006-0006-3
DO - 10.1007/s00408-006-0006-3
M3 - Article
C2 - 17111093
AN - SCOPUS:33845426714
VL - 184
SP - 363
EP - 368
JO - Lung
JF - Lung
SN - 0341-2040
IS - 6
ER -