TY - JOUR
T1 - Acute cardiopulmonary effects of pancuronium bromide in mechanically ventilated newborn infants
AU - Runkle, Beatriz
AU - Bancalari, Eduardo
N1 - Funding Information:
From the Division of Neonatolog)', Department of Pediatrics. University of Miami School of Medicine. Supported in part by the State of Florida. Department of Health and Rehabilitative Services. Children's Medical Services; National tteart, Lttng and Blood Institute (grant 5 ROI tlL25023-03): and University of Miami Project: New Born Reprint requests: Eduardo Banealari. M.D., University of Miami, Department of Pediatrics (R-131). Division of Neonatology, P.O. Box 016960, Miami. FL 33101.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1984/4
Y1 - 1984/4
N2 - The short-term effects of muscle relaxation with pancuronium bromide on arterial blood gas values, heart rate, and arterial blood pressure were studied in 49 neonates receiving mechanical ventilation. After pancuronium administration, mean PaO2 increased from 61.9±30.0 to 80.9±52.8 mm Hg (P=0.006), mean PaCO2 decreased from 40.1±13.0 to 37.5±13.3 mm Hg (P=0.03), and mean heart rate rose from 146.2±24.9 to 161.0±20.5 beats/min (P<0.001). Arterial blood pressure did not change significantly. When results were analyzed by diagnosis (meconium aspiration syndrome, hyaline membrane disease, pneumonia), only infants with meconium aspiration syndrome had a significant improvement in oxygenation (P=0.008). Six of 18 patients with hyaline membrane disease responded to muscle relaxation, with a decrease in PaO2 of 10mm Hg or more. No significant correlation was found between change in PaO2 and birth weight, gestational age, postnatal age, or change in heart rate. A weak correlation (r=-0.37, P<0.006) was observed between change in PaO2 and change in PaCO2. Although the reasons for the divergence in response in different groups of patients are not entirely clear, the risk of deterioration with pancuronium therapy should be kept in mind, particularly if treatment in an infant with hyaline membrane disease is being considered.
AB - The short-term effects of muscle relaxation with pancuronium bromide on arterial blood gas values, heart rate, and arterial blood pressure were studied in 49 neonates receiving mechanical ventilation. After pancuronium administration, mean PaO2 increased from 61.9±30.0 to 80.9±52.8 mm Hg (P=0.006), mean PaCO2 decreased from 40.1±13.0 to 37.5±13.3 mm Hg (P=0.03), and mean heart rate rose from 146.2±24.9 to 161.0±20.5 beats/min (P<0.001). Arterial blood pressure did not change significantly. When results were analyzed by diagnosis (meconium aspiration syndrome, hyaline membrane disease, pneumonia), only infants with meconium aspiration syndrome had a significant improvement in oxygenation (P=0.008). Six of 18 patients with hyaline membrane disease responded to muscle relaxation, with a decrease in PaO2 of 10mm Hg or more. No significant correlation was found between change in PaO2 and birth weight, gestational age, postnatal age, or change in heart rate. A weak correlation (r=-0.37, P<0.006) was observed between change in PaO2 and change in PaCO2. Although the reasons for the divergence in response in different groups of patients are not entirely clear, the risk of deterioration with pancuronium therapy should be kept in mind, particularly if treatment in an infant with hyaline membrane disease is being considered.
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U2 - 10.1016/S0022-3476(84)80563-6
DO - 10.1016/S0022-3476(84)80563-6
M3 - Article
C2 - 6707824
AN - SCOPUS:0021267010
VL - 104
SP - 614
EP - 617
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 4
ER -