Acute and chronic effects of melatonin as an anticonvulsant in male gerbils

Thomas Champney, William H. Hanneman, Marie E. Legare, Kevin Appel

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Melatonin, a hormone produced in the pineal gland and released into the general circulation on a diurnal basis, has been implicated in many behavioral processes, where it has been shown to have anxiolytic, sedative, and anticonvulsant effects. Male gerbils (Meriones unguiculatus) injected daily with melatonin (25 μg, s.c.) exhibited a reduced seizure response to pentylenetetrazol (PTZ, 60 mg/kg, s.c.). The present studies determined 1) whether melatonin's effect was related to the time of day that it was administered and 2) whether a single acute injection of melatonin at various doses could produce anticonvulsant activity. Gerbils provided with 13 weeks of daily melatonin injections (25 μg, s.c.) exhibited fewer convulsions after PTZ treatment irrespective of the time of day melatonin was injected. In addition, the melatonin-treated gerbils had lower mortality rates (1/12) than the untreated or vehicle-injected gerbils (5/12). On the other hand, single acute injections of melatonin (0.1-10 mg/kg, i.p.) produced no anticonvulsant activity. It appears that the anticonvulsant effects of melatonin occur only after the animals are chronically exposed to the indole. In addition, melatonin's anticonvulsant ability may utilize a different mechanism than those involved in its endocrine effects, since no diurnal difference in melatonin's anticonvulsant activity was observed.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalJournal of Pineal Research
Volume20
Issue number2
StatePublished - Mar 1 1996
Externally publishedYes

Fingerprint

Gerbillinae
Melatonin
Anticonvulsants
Injections
Seizures
Pentylenetetrazole
Pineal Gland
Anti-Anxiety Agents
Hypnotics and Sedatives
Hormones

Keywords

  • Epilepsy
  • Gerbil
  • Melatonin
  • Pentylenetetrazol
  • Seizures

ASJC Scopus subject areas

  • Endocrinology

Cite this

Acute and chronic effects of melatonin as an anticonvulsant in male gerbils. / Champney, Thomas; Hanneman, William H.; Legare, Marie E.; Appel, Kevin.

In: Journal of Pineal Research, Vol. 20, No. 2, 01.03.1996, p. 79-83.

Research output: Contribution to journalArticle

Champney, T, Hanneman, WH, Legare, ME & Appel, K 1996, 'Acute and chronic effects of melatonin as an anticonvulsant in male gerbils', Journal of Pineal Research, vol. 20, no. 2, pp. 79-83.
Champney, Thomas ; Hanneman, William H. ; Legare, Marie E. ; Appel, Kevin. / Acute and chronic effects of melatonin as an anticonvulsant in male gerbils. In: Journal of Pineal Research. 1996 ; Vol. 20, No. 2. pp. 79-83.
@article{b968ef820a3249688aa62474bfb44905,
title = "Acute and chronic effects of melatonin as an anticonvulsant in male gerbils",
abstract = "Melatonin, a hormone produced in the pineal gland and released into the general circulation on a diurnal basis, has been implicated in many behavioral processes, where it has been shown to have anxiolytic, sedative, and anticonvulsant effects. Male gerbils (Meriones unguiculatus) injected daily with melatonin (25 μg, s.c.) exhibited a reduced seizure response to pentylenetetrazol (PTZ, 60 mg/kg, s.c.). The present studies determined 1) whether melatonin's effect was related to the time of day that it was administered and 2) whether a single acute injection of melatonin at various doses could produce anticonvulsant activity. Gerbils provided with 13 weeks of daily melatonin injections (25 μg, s.c.) exhibited fewer convulsions after PTZ treatment irrespective of the time of day melatonin was injected. In addition, the melatonin-treated gerbils had lower mortality rates (1/12) than the untreated or vehicle-injected gerbils (5/12). On the other hand, single acute injections of melatonin (0.1-10 mg/kg, i.p.) produced no anticonvulsant activity. It appears that the anticonvulsant effects of melatonin occur only after the animals are chronically exposed to the indole. In addition, melatonin's anticonvulsant ability may utilize a different mechanism than those involved in its endocrine effects, since no diurnal difference in melatonin's anticonvulsant activity was observed.",
keywords = "Epilepsy, Gerbil, Melatonin, Pentylenetetrazol, Seizures",
author = "Thomas Champney and Hanneman, {William H.} and Legare, {Marie E.} and Kevin Appel",
year = "1996",
month = "3",
day = "1",
language = "English",
volume = "20",
pages = "79--83",
journal = "Journal of Pineal Research",
issn = "0742-3098",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Acute and chronic effects of melatonin as an anticonvulsant in male gerbils

AU - Champney, Thomas

AU - Hanneman, William H.

AU - Legare, Marie E.

AU - Appel, Kevin

PY - 1996/3/1

Y1 - 1996/3/1

N2 - Melatonin, a hormone produced in the pineal gland and released into the general circulation on a diurnal basis, has been implicated in many behavioral processes, where it has been shown to have anxiolytic, sedative, and anticonvulsant effects. Male gerbils (Meriones unguiculatus) injected daily with melatonin (25 μg, s.c.) exhibited a reduced seizure response to pentylenetetrazol (PTZ, 60 mg/kg, s.c.). The present studies determined 1) whether melatonin's effect was related to the time of day that it was administered and 2) whether a single acute injection of melatonin at various doses could produce anticonvulsant activity. Gerbils provided with 13 weeks of daily melatonin injections (25 μg, s.c.) exhibited fewer convulsions after PTZ treatment irrespective of the time of day melatonin was injected. In addition, the melatonin-treated gerbils had lower mortality rates (1/12) than the untreated or vehicle-injected gerbils (5/12). On the other hand, single acute injections of melatonin (0.1-10 mg/kg, i.p.) produced no anticonvulsant activity. It appears that the anticonvulsant effects of melatonin occur only after the animals are chronically exposed to the indole. In addition, melatonin's anticonvulsant ability may utilize a different mechanism than those involved in its endocrine effects, since no diurnal difference in melatonin's anticonvulsant activity was observed.

AB - Melatonin, a hormone produced in the pineal gland and released into the general circulation on a diurnal basis, has been implicated in many behavioral processes, where it has been shown to have anxiolytic, sedative, and anticonvulsant effects. Male gerbils (Meriones unguiculatus) injected daily with melatonin (25 μg, s.c.) exhibited a reduced seizure response to pentylenetetrazol (PTZ, 60 mg/kg, s.c.). The present studies determined 1) whether melatonin's effect was related to the time of day that it was administered and 2) whether a single acute injection of melatonin at various doses could produce anticonvulsant activity. Gerbils provided with 13 weeks of daily melatonin injections (25 μg, s.c.) exhibited fewer convulsions after PTZ treatment irrespective of the time of day melatonin was injected. In addition, the melatonin-treated gerbils had lower mortality rates (1/12) than the untreated or vehicle-injected gerbils (5/12). On the other hand, single acute injections of melatonin (0.1-10 mg/kg, i.p.) produced no anticonvulsant activity. It appears that the anticonvulsant effects of melatonin occur only after the animals are chronically exposed to the indole. In addition, melatonin's anticonvulsant ability may utilize a different mechanism than those involved in its endocrine effects, since no diurnal difference in melatonin's anticonvulsant activity was observed.

KW - Epilepsy

KW - Gerbil

KW - Melatonin

KW - Pentylenetetrazol

KW - Seizures

UR - http://www.scopus.com/inward/record.url?scp=0030099590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030099590&partnerID=8YFLogxK

M3 - Article

C2 - 8815191

AN - SCOPUS:0030099590

VL - 20

SP - 79

EP - 83

JO - Journal of Pineal Research

JF - Journal of Pineal Research

SN - 0742-3098

IS - 2

ER -