Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo

S. L. Andersen, Arba L Ager, P. McGreevy, B. G. Schuster, D. Wesche, R. Kuschner, C. Ohrt, W. Ellis, R. Rossan, J. Berman

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We compared the efficacy of azithromycin to the clinical antimalarial doxycycline in Plasmodium berghei-infected mice and in P. falciparum-infected Aotus monkeys. When mice were administered drug orally twice a day for three days, the minimum total dose of azithromycin that cured all mice was 768 mg/kg. Doxycycline at a dose of 1,536 mg/kg cured no mice. The efficacy of fast-acting blood schizonticides (quinine, halofantrine, artemisinin) against P. berghei was augmented by azithromycin. In monkey experiments in which there were two animals per experimental group, azithromycin (100 mg/kg/day for seven days) eliminated parasitemia; azithromycin (30 mg/kg/day) initially cleared 99.8-100% of the parasites with recrudescence in the one completely cleared case. Doxycycline (30 mg/kg/day) cleared 100% of the parasites with recrudescence in both cleared cases. Since azithromycin can be clinically administered at a somewhat higher daily dosage than doxycycline, the data suggest that it may be possible to replace drugs of the tetracycline class with azithromycin in combination with fast-acting blood schizonticides for the treatment of P. falciparum infection.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume52
Issue number2
StatePublished - 1995
Externally publishedYes

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Antiprotozoal Agents
Azithromycin
Plasmodium
Rodentia
Doxycycline
Plasmodium berghei
Haplorhini
Parasites
Recurrence
Quinine
Parasitemia
Antimalarials
Tetracycline
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Andersen, S. L., Ager, A. L., McGreevy, P., Schuster, B. G., Wesche, D., Kuschner, R., ... Berman, J. (1995). Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo. American Journal of Tropical Medicine and Hygiene, 52(2), 159-161.

Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo. / Andersen, S. L.; Ager, Arba L; McGreevy, P.; Schuster, B. G.; Wesche, D.; Kuschner, R.; Ohrt, C.; Ellis, W.; Rossan, R.; Berman, J.

In: American Journal of Tropical Medicine and Hygiene, Vol. 52, No. 2, 1995, p. 159-161.

Research output: Contribution to journalArticle

Andersen, SL, Ager, AL, McGreevy, P, Schuster, BG, Wesche, D, Kuschner, R, Ohrt, C, Ellis, W, Rossan, R & Berman, J 1995, 'Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo', American Journal of Tropical Medicine and Hygiene, vol. 52, no. 2, pp. 159-161.
Andersen SL, Ager AL, McGreevy P, Schuster BG, Wesche D, Kuschner R et al. Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo. American Journal of Tropical Medicine and Hygiene. 1995;52(2):159-161.
Andersen, S. L. ; Ager, Arba L ; McGreevy, P. ; Schuster, B. G. ; Wesche, D. ; Kuschner, R. ; Ohrt, C. ; Ellis, W. ; Rossan, R. ; Berman, J. / Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo. In: American Journal of Tropical Medicine and Hygiene. 1995 ; Vol. 52, No. 2. pp. 159-161.
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