Activity-dependent depression of nerve action potential by phenytoin

Gavriel David, Michael E. Selzer, Yoel Yaari

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The action of the anticonvulsant drug phenytoin was investigated on the responsiveness of isolated amphibian and human nerves to repetitive stimulation. At low frequencies of stimulation (0.5-25 Hz) the drug (at a concentration of 0.1 mM) had no notable effect on the compound nerve action potential. By contrast, at higher rates of stimulation (50-300 Hz), it produced a progressive decrease in amplitude and integral of the compound action potential. This effect was positively correlated with the frequency of nerve activation and was markedly enhanced by elevating the extracellular K+ concentration. Thus, phenytoin induces a use- and frequency-dependent depression of axon conduction, which may contribute to its preferential suppression of the spread of high-frequency seizure discharge in the brain.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalNeuroscience Letters
Volume66
Issue number2
DOIs
StatePublished - May 15 1986
Externally publishedYes

Fingerprint

Phenytoin
Action Potentials
Amphibians
Anticonvulsants
Axons
Seizures
Brain
Pharmaceutical Preparations

Keywords

  • antiepileptic drug
  • frequency-dependence-action potential
  • frog
  • phenytoin
  • sciatic nerve
  • use-dependence

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Activity-dependent depression of nerve action potential by phenytoin. / David, Gavriel; Selzer, Michael E.; Yaari, Yoel.

In: Neuroscience Letters, Vol. 66, No. 2, 15.05.1986, p. 163-168.

Research output: Contribution to journalArticle

David, Gavriel ; Selzer, Michael E. ; Yaari, Yoel. / Activity-dependent depression of nerve action potential by phenytoin. In: Neuroscience Letters. 1986 ; Vol. 66, No. 2. pp. 163-168.
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