Activity and specificity of synthetic thyrotropin-releasing hormone in man

C. Y. Bowers; A. V. Schally; D. S. Schalch; C. Gual; A. J. Kastin; K. Folkers

doi:10.1016/0006-291X(70)90583-8

Activity and specificity of synthetic thyrotropin-releasing hormone in man

C. Y. Bowers, A. V. Schally, D. S. Schalch, C. Gual, A. J. Kastin, K. Folkers

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The serum levels of thyrotropin (TSH) increased two minutes after a quick single iv. injection of 800 μg of synthetic thyrotropin releasing hormone (TRH) into a normal male subject. The peak elevation of TSH occurred after 30 minutes, and was 370% higher than the level at 0 time; after 3 hours, the level decreased to normal. The levels of GH, LH, and FSH did not significantly change, but the plasma level of cortisol rose slightly. These studies show the hormonal activity and specificity of synthetic TRH to release TSH in man and indicate its future use for studying the pituitary-thyroid system of man in health and disease.

Original language	English (US)
Pages (from-to)	352-355
Number of pages	4
Journal	Biochemical and biophysical research communications
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(70)90583-8
State	Published - May 11 1970
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "The serum levels of thyrotropin (TSH) increased two minutes after a quick single iv. injection of 800 μg of synthetic thyrotropin releasing hormone (TRH) into a normal male subject. The peak elevation of TSH occurred after 30 minutes, and was 370% higher than the level at 0 time; after 3 hours, the level decreased to normal. The levels of GH, LH, and FSH did not significantly change, but the plasma level of cortisol rose slightly. These studies show the hormonal activity and specificity of synthetic TRH to release TSH in man and indicate its future use for studying the pituitary-thyroid system of man in health and disease.",

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AU - Bowers, C. Y.

AU - Schally, A. V.

AU - Schalch, D. S.

AU - Gual, C.

AU - Kastin, A. J.

AU - Folkers, K.

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