Active subjects with autoimmune type 1 diabetes have better metabolic profiles than sedentary controls

M. Adamo, R. Codella, F. Casiraghi, A. Ferrulli, C. Macrì, E. Bazzigaluppi, I. Terruzzi, Luca A Inverardi, Camillo Ricordi, L. Luzi

Research output: Contribution to journalArticle

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Abstract

Previous studies in humans with type 1 diabetes mellitus (T1D) and in nonobese diabetic mice have investigated the beneficial immunomodulatory potential of aerobic physical activity. Performing high volume of aerobic exercise may favorably regulate autoimmunity in diabetes. We tested whether increased physical activity is a self-sufficient positive factor in T1D subjects. During a 3-month observational period, active (six males; 40.5 ± 6.1 years; BMI: 24.5 ± 2.1) and sedentary (four males, three females; 35.9 ± 8.9 years; BMI: 25.7 ± 3.8) T1D individuals on insulin pump therapy were studied for metabolic, inflammatory, and autoimmune parameters. At baseline and at the end of a 3-month period, glycosylated hemoglobin (HbA1c), autoantibodies (anti-GAD, anti-ZnT8, anti-IA2, and ICA) and proinflammatory cytokines (IL-6 and TNF-a) were evaluated. During the third month of the period, physically active T1D patients showed a significant reduction in the average glucose levels (−9%, p = 0.025, by CGM) compared to the first month values, and even their hyperglycemic episodes (>180 mg/dl) diminished significantly (−24.2%, p = 0.032 vs. first month). Moreover, active T1D subjects exhibited an improved body composition with respect to sedentary controls. No significant changes were detected as to the autoimmune and inflammatory profiles. This study confirms the beneficial role of physical exercise associated with insulin pump therapy in order to improve metabolic control in individuals with T1D. These preliminary positive observations need to be challenged in a prolonged interventional follow-up.

Original languageEnglish (US)
Pages (from-to)23-32
Number of pages10
JournalCell Transplantation
Volume26
Issue number1
DOIs
StatePublished - 2017

Fingerprint

Metabolome
Medical problems
Type 1 Diabetes Mellitus
Exercise
Insulin
Pumps
Inbred NOD Mouse
Glycosylated Hemoglobin A
Body Composition
Autoimmunity
Hemoglobin
Autoantibodies
Independent component analysis
Interleukin-6
Glucose
Cytokines
Therapeutics
Chemical analysis

Keywords

  • Continuous glucose monitoring (CGM)
  • Insulin pump therapy
  • Physical activity
  • Type 1 diabetes (T1D)

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

Cite this

Adamo, M., Codella, R., Casiraghi, F., Ferrulli, A., Macrì, C., Bazzigaluppi, E., ... Luzi, L. (2017). Active subjects with autoimmune type 1 diabetes have better metabolic profiles than sedentary controls. Cell Transplantation, 26(1), 23-32. https://doi.org/10.3727/096368916X693022

Active subjects with autoimmune type 1 diabetes have better metabolic profiles than sedentary controls. / Adamo, M.; Codella, R.; Casiraghi, F.; Ferrulli, A.; Macrì, C.; Bazzigaluppi, E.; Terruzzi, I.; Inverardi, Luca A; Ricordi, Camillo; Luzi, L.

In: Cell Transplantation, Vol. 26, No. 1, 2017, p. 23-32.

Research output: Contribution to journalArticle

Adamo, M, Codella, R, Casiraghi, F, Ferrulli, A, Macrì, C, Bazzigaluppi, E, Terruzzi, I, Inverardi, LA, Ricordi, C & Luzi, L 2017, 'Active subjects with autoimmune type 1 diabetes have better metabolic profiles than sedentary controls', Cell Transplantation, vol. 26, no. 1, pp. 23-32. https://doi.org/10.3727/096368916X693022
Adamo, M. ; Codella, R. ; Casiraghi, F. ; Ferrulli, A. ; Macrì, C. ; Bazzigaluppi, E. ; Terruzzi, I. ; Inverardi, Luca A ; Ricordi, Camillo ; Luzi, L. / Active subjects with autoimmune type 1 diabetes have better metabolic profiles than sedentary controls. In: Cell Transplantation. 2017 ; Vol. 26, No. 1. pp. 23-32.
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