Abstract
After the completion of skin development, angiogenesis, i.e., the growth of new capillaries from preexisting blood vessels, is held to occur in the skin only under pathologic conditions. It has long been noted, however, that hair follicle cycling is associated with prominent changes in skin perfusion, that the epithelial hair bulbs of anagen follicles display angiogenic properties, and that the follicular dermal papilla can produce angiogenic factors. Despite these suggestive observations, no formal proof is as yet available for the concept that angiogenesis is a physiologic event that occurs all over the mature mammalian integument whenever hair follicles switch from resting (telogen) to active growth (anagen). This study uses quantitative histomorphometry and double-immunohistologic detection techniques for the demarcation of proliferating endothelial cells, to show that synchronized hair follicle cycling in adolescent C57BL/6 mice is associated with substantial angiogenesis, and that inhibiting angiogenesis in vivo by the intraperitoneal application of a fumagillin derivative retards experimentally induced anagen development in these mice. Thus, angiogenesis is a physiologic event in normal postnatal murine skin, apparently is dictated by the hair follicle, and appears to be required for normal anagen development. Anagen-associated angiogenesis offers an attractive model for identifying the physiologic controls of cutaneous angiogenesis, and an interesting system for screening the effects of potential antiangiogenic drugs in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 909-916 |
| Number of pages | 8 |
| Journal | Journal of Investigative Dermatology |
| Volume | 114 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2000 |
| Externally published | Yes |
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Keywords
- C57BL/6
- PECAM-1
- Skin
- TNP-470
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
- Cell Biology
Cite this
Active hair growth (anagen) is associated with angiogenesis. / Mecklenburg, Lars; Tobin, Desmond J.; Müller-Röver, Sven; Handjiski, Bori; Wendt, Gunnar; Peters, Eva M.J.; Pohl, Susanne; Moll, Ingrid; Paus, Ralf.
In: Journal of Investigative Dermatology, Vol. 114, No. 5, 01.01.2000, p. 909-916.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Active hair growth (anagen) is associated with angiogenesis
AU - Mecklenburg, Lars
AU - Tobin, Desmond J.
AU - Müller-Röver, Sven
AU - Handjiski, Bori
AU - Wendt, Gunnar
AU - Peters, Eva M.J.
AU - Pohl, Susanne
AU - Moll, Ingrid
AU - Paus, Ralf
PY - 2000/1/1
Y1 - 2000/1/1
N2 - After the completion of skin development, angiogenesis, i.e., the growth of new capillaries from preexisting blood vessels, is held to occur in the skin only under pathologic conditions. It has long been noted, however, that hair follicle cycling is associated with prominent changes in skin perfusion, that the epithelial hair bulbs of anagen follicles display angiogenic properties, and that the follicular dermal papilla can produce angiogenic factors. Despite these suggestive observations, no formal proof is as yet available for the concept that angiogenesis is a physiologic event that occurs all over the mature mammalian integument whenever hair follicles switch from resting (telogen) to active growth (anagen). This study uses quantitative histomorphometry and double-immunohistologic detection techniques for the demarcation of proliferating endothelial cells, to show that synchronized hair follicle cycling in adolescent C57BL/6 mice is associated with substantial angiogenesis, and that inhibiting angiogenesis in vivo by the intraperitoneal application of a fumagillin derivative retards experimentally induced anagen development in these mice. Thus, angiogenesis is a physiologic event in normal postnatal murine skin, apparently is dictated by the hair follicle, and appears to be required for normal anagen development. Anagen-associated angiogenesis offers an attractive model for identifying the physiologic controls of cutaneous angiogenesis, and an interesting system for screening the effects of potential antiangiogenic drugs in vivo.
AB - After the completion of skin development, angiogenesis, i.e., the growth of new capillaries from preexisting blood vessels, is held to occur in the skin only under pathologic conditions. It has long been noted, however, that hair follicle cycling is associated with prominent changes in skin perfusion, that the epithelial hair bulbs of anagen follicles display angiogenic properties, and that the follicular dermal papilla can produce angiogenic factors. Despite these suggestive observations, no formal proof is as yet available for the concept that angiogenesis is a physiologic event that occurs all over the mature mammalian integument whenever hair follicles switch from resting (telogen) to active growth (anagen). This study uses quantitative histomorphometry and double-immunohistologic detection techniques for the demarcation of proliferating endothelial cells, to show that synchronized hair follicle cycling in adolescent C57BL/6 mice is associated with substantial angiogenesis, and that inhibiting angiogenesis in vivo by the intraperitoneal application of a fumagillin derivative retards experimentally induced anagen development in these mice. Thus, angiogenesis is a physiologic event in normal postnatal murine skin, apparently is dictated by the hair follicle, and appears to be required for normal anagen development. Anagen-associated angiogenesis offers an attractive model for identifying the physiologic controls of cutaneous angiogenesis, and an interesting system for screening the effects of potential antiangiogenic drugs in vivo.
KW - C57BL/6
KW - PECAM-1
KW - Skin
KW - TNP-470
UR - http://www.scopus.com/inward/record.url?scp=0034023353&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034023353&partnerID=8YFLogxK
U2 - 10.1046/j.1523-1747.2000.00954.x
DO - 10.1046/j.1523-1747.2000.00954.x
M3 - Article
C2 - 10771470
AN - SCOPUS:0034023353
VL - 114
SP - 909
EP - 916
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 5
ER -