Active hair growth (anagen) is associated with angiogenesis

Lars Mecklenburg, Desmond J. Tobin, Sven Müller-Röver, Bori Handjiski, Gunnar Wendt, Eva M.J. Peters, Susanne Pohl, Ingrid Moll, Ralf Paus

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

After the completion of skin development, angiogenesis, i.e., the growth of new capillaries from preexisting blood vessels, is held to occur in the skin only under pathologic conditions. It has long been noted, however, that hair follicle cycling is associated with prominent changes in skin perfusion, that the epithelial hair bulbs of anagen follicles display angiogenic properties, and that the follicular dermal papilla can produce angiogenic factors. Despite these suggestive observations, no formal proof is as yet available for the concept that angiogenesis is a physiologic event that occurs all over the mature mammalian integument whenever hair follicles switch from resting (telogen) to active growth (anagen). This study uses quantitative histomorphometry and double-immunohistologic detection techniques for the demarcation of proliferating endothelial cells, to show that synchronized hair follicle cycling in adolescent C57BL/6 mice is associated with substantial angiogenesis, and that inhibiting angiogenesis in vivo by the intraperitoneal application of a fumagillin derivative retards experimentally induced anagen development in these mice. Thus, angiogenesis is a physiologic event in normal postnatal murine skin, apparently is dictated by the hair follicle, and appears to be required for normal anagen development. Anagen-associated angiogenesis offers an attractive model for identifying the physiologic controls of cutaneous angiogenesis, and an interesting system for screening the effects of potential antiangiogenic drugs in vivo.

Original languageEnglish (US)
Pages (from-to)909-916
Number of pages8
JournalJournal of Investigative Dermatology
Volume114
Issue number5
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Hair
Skin
Hair Follicle
Growth
Angiogenesis Inducing Agents
Endothelial cells
Blood vessels
Screening
Switches
Derivatives
Inbred C57BL Mouse
Blood Vessels
Endothelial Cells
Perfusion
Pharmaceutical Preparations

Keywords

  • C57BL/6
  • PECAM-1
  • Skin
  • TNP-470

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Mecklenburg, L., Tobin, D. J., Müller-Röver, S., Handjiski, B., Wendt, G., Peters, E. M. J., ... Paus, R. (2000). Active hair growth (anagen) is associated with angiogenesis. Journal of Investigative Dermatology, 114(5), 909-916. https://doi.org/10.1046/j.1523-1747.2000.00954.x

Active hair growth (anagen) is associated with angiogenesis. / Mecklenburg, Lars; Tobin, Desmond J.; Müller-Röver, Sven; Handjiski, Bori; Wendt, Gunnar; Peters, Eva M.J.; Pohl, Susanne; Moll, Ingrid; Paus, Ralf.

In: Journal of Investigative Dermatology, Vol. 114, No. 5, 01.01.2000, p. 909-916.

Research output: Contribution to journalArticle

Mecklenburg, L, Tobin, DJ, Müller-Röver, S, Handjiski, B, Wendt, G, Peters, EMJ, Pohl, S, Moll, I & Paus, R 2000, 'Active hair growth (anagen) is associated with angiogenesis', Journal of Investigative Dermatology, vol. 114, no. 5, pp. 909-916. https://doi.org/10.1046/j.1523-1747.2000.00954.x
Mecklenburg L, Tobin DJ, Müller-Röver S, Handjiski B, Wendt G, Peters EMJ et al. Active hair growth (anagen) is associated with angiogenesis. Journal of Investigative Dermatology. 2000 Jan 1;114(5):909-916. https://doi.org/10.1046/j.1523-1747.2000.00954.x
Mecklenburg, Lars ; Tobin, Desmond J. ; Müller-Röver, Sven ; Handjiski, Bori ; Wendt, Gunnar ; Peters, Eva M.J. ; Pohl, Susanne ; Moll, Ingrid ; Paus, Ralf. / Active hair growth (anagen) is associated with angiogenesis. In: Journal of Investigative Dermatology. 2000 ; Vol. 114, No. 5. pp. 909-916.
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