TY - JOUR
T1 - Active coping style is associated with natural killer cell cytotoxicity in asymptomatic HIV-1 seropositive homosexual men
AU - Goodkin, Karl
AU - Blaney, Nancy T.
AU - Feaster, Daniel
AU - Fletcher, Mary Ann
AU - Baum, Marianna K.
AU - Mantero-Atienza, Emilio
AU - Klimas, Nancy G.
AU - Millon, Carrie
AU - Szapocznik, Jose
AU - Eisdorfer, Carl
N1 - Funding Information:
Acknowledgemenfs-We would like to acknowledge the supporto f the National Institute of Mental Health Grant (P50MH43455) for the Center for the Biopsychological Study of AIDS as well as 1 ROl MH48628-01. In addition, we would like to acknowledge the Sylvester Comprehensive Cancer Center of the University of Miami School of Medicine and the Helen Dowling Institute for Biopsychological Medicine, Rotterdam, The Netherlands for administrative support. I would also like to acknowledge Robert Morgan, PhD, for his helpful supervision of the statistical analyses conducted; Michael Antoni, PhD, and Arthur LaPerriere, PhD, for their incisive reviews of the manuscript; Mr Ron Stubbs and MS Gladys Chayeb for help in its preparation; and Ken Christianson, MA, Victoria Dickman, Alicia Cehallos, PhD, Michael Uselmann, MS, and Janet Yodsnukis, MA, for their efforts in data collection and subject management. Finally, I would like to acknowledge the community agencies caring for the HIV-l infected in Miami for referring subjects to this study.
PY - 1992/10
Y1 - 1992/10
N2 - The aim of this study was to examine the hypothesis that a psychosocial model was associated with natural killer cell cytotoxicity (NKCC) in HIV-1 infection. A sample of 62 HIV-1 seropositive homosexual men at CDC stages II and III were given a psychosocial battery assessing life stressors, social support, and coping style. A regression model quantifying these variables along with control variables for alcohol use, substance use and nutritional status was estimated. Active coping style was directly and positively associated with NKCC, and trends toward a negative relationship of life stressors and a buffering effect of social support on lifes stressors were also observed. The results suggest that (1) control variables should be included with psychosocial models and that (2) psychosocial factors, especially active coping, may have a deterrent effect on loss of NK cell function. Active coping style may merit a specific focus in future research of life stressors and the immune system.
AB - The aim of this study was to examine the hypothesis that a psychosocial model was associated with natural killer cell cytotoxicity (NKCC) in HIV-1 infection. A sample of 62 HIV-1 seropositive homosexual men at CDC stages II and III were given a psychosocial battery assessing life stressors, social support, and coping style. A regression model quantifying these variables along with control variables for alcohol use, substance use and nutritional status was estimated. Active coping style was directly and positively associated with NKCC, and trends toward a negative relationship of life stressors and a buffering effect of social support on lifes stressors were also observed. The results suggest that (1) control variables should be included with psychosocial models and that (2) psychosocial factors, especially active coping, may have a deterrent effect on loss of NK cell function. Active coping style may merit a specific focus in future research of life stressors and the immune system.
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U2 - 10.1016/0022-3999(92)90053-5
DO - 10.1016/0022-3999(92)90053-5
M3 - Article
C2 - 1403998
AN - SCOPUS:0026665367
VL - 36
SP - 635
EP - 650
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
SN - 0022-3999
IS - 7
ER -
