Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

C. M. Pombo, J. H. Kehrl, I. Sanchez, P. Katz, J. Avruch, L. I. Zon, J. R. Woodgett, T. Force, J. M. Kyriakis

Research output: Contribution to journalArticle

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Abstract

Eukaryotic cells respond to different extracellular stimuli by recruiting homologous signalling pathways that use members of the MEKK, MEK and ERK families of protein kinases. The MEKK→MEK→ERK core pathways of Saccharomyces cerevisiae may themselves be regulated by members of the STE20 family of protein kinases. Here we report specific activation of the mammalian stress-activated protein kinase (SAPK) pathway by germinal centre kinase (CGK), a human STE20 homologue, SAPKs, members of the ERK family, are activated n situ by inflammatory stimuli, including tumour-necrosis factor (TNF) and interleukin-1, and phosphorylate and probably stimulate the transactivation function of c-Jun. Although GCK is found in manly tissues, its expression in lymphoid follicles is restricted to the cells of the germinal centre, where it may participate in B-cell differentiation. Activation of the SAPK pathway by GCK illustrates further the striking conservation of eukaryotic signalling mechanisms and defines the first physiological function of a mammalian Ste20.

Original languageEnglish
Pages (from-to)750-754
Number of pages5
JournalNature
Volume377
Issue number6551
StatePublished - Jan 1 1995
Externally publishedYes

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Heat-Shock Proteins
Protein Kinases
MAP Kinase Kinase Kinases
Germinal Center
Mitogen-Activated Protein Kinase Kinases
Eukaryotic Cells
Interleukin-1
Transcriptional Activation
Saccharomyces cerevisiae
Cell Differentiation
B-Lymphocytes
Tumor Necrosis Factor-alpha
germinal center kinases

ASJC Scopus subject areas

  • General

Cite this

Pombo, C. M., Kehrl, J. H., Sanchez, I., Katz, P., Avruch, J., Zon, L. I., ... Kyriakis, J. M. (1995). Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. Nature, 377(6551), 750-754.

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. / Pombo, C. M.; Kehrl, J. H.; Sanchez, I.; Katz, P.; Avruch, J.; Zon, L. I.; Woodgett, J. R.; Force, T.; Kyriakis, J. M.

In: Nature, Vol. 377, No. 6551, 01.01.1995, p. 750-754.

Research output: Contribution to journalArticle

Pombo, CM, Kehrl, JH, Sanchez, I, Katz, P, Avruch, J, Zon, LI, Woodgett, JR, Force, T & Kyriakis, JM 1995, 'Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase', Nature, vol. 377, no. 6551, pp. 750-754.
Pombo CM, Kehrl JH, Sanchez I, Katz P, Avruch J, Zon LI et al. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. Nature. 1995 Jan 1;377(6551):750-754.
Pombo, C. M. ; Kehrl, J. H. ; Sanchez, I. ; Katz, P. ; Avruch, J. ; Zon, L. I. ; Woodgett, J. R. ; Force, T. ; Kyriakis, J. M. / Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. In: Nature. 1995 ; Vol. 377, No. 6551. pp. 750-754.
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AU - Zon, L. I.

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