Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal: A fMRI study

K. Luan Phan, Stephan F. Taylor, Robert C. Welsh, Laura R. Decker, Douglas C. Noll, Thomas E. Nichols, Jennifer C Britton, Israel Liberzon

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Background: Significant differences between individual responses to emotional stimuli can be important for the study of emotion. We investigated whether incorporating individual ratings of emotional arousal in the analysis of functional magnetic resonance imaging (fMRI) data improves the detection of activation in the medial prefrontal cortex (MPFC) and sublenticular extended amygdala (SLEA), areas implicated in the processing of emotional salience. Methods: Healthy subjects viewed counterbalanced blocks of aversive, nonaversive, and blank images. Outside the scanner, they rated the intensity of emotional arousal (salience) of each presented picture. Results: Incorporating the subject's response to each stimulus by using individualized regressors produced more robust activations within MPFC and SLEA compared with a simple boxcar regressor, identical for all subjects. Conclusions: Our findings demonstrate that individual behavioral data are useful in improving detection of activation in block-design functional imaging studies.

Original languageEnglish
Pages (from-to)211-215
Number of pages5
JournalBiological Psychiatry
Volume53
Issue number3
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

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Arousal
Amygdala
Prefrontal Cortex
Magnetic Resonance Imaging
Individuality
Healthy Volunteers
Emotions

Keywords

  • Arousal
  • Emotion
  • Extended amygdala
  • Functional magnetic resonance imaging
  • Individual differences
  • Medial prefrontal cortex

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Phan, K. L., Taylor, S. F., Welsh, R. C., Decker, L. R., Noll, D. C., Nichols, T. E., ... Liberzon, I. (2003). Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal: A fMRI study. Biological Psychiatry, 53(3), 211-215. https://doi.org/10.1016/S0006-3223(02)01485-3

Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal : A fMRI study. / Phan, K. Luan; Taylor, Stephan F.; Welsh, Robert C.; Decker, Laura R.; Noll, Douglas C.; Nichols, Thomas E.; Britton, Jennifer C; Liberzon, Israel.

In: Biological Psychiatry, Vol. 53, No. 3, 01.02.2003, p. 211-215.

Research output: Contribution to journalArticle

Phan, K. Luan ; Taylor, Stephan F. ; Welsh, Robert C. ; Decker, Laura R. ; Noll, Douglas C. ; Nichols, Thomas E. ; Britton, Jennifer C ; Liberzon, Israel. / Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal : A fMRI study. In: Biological Psychiatry. 2003 ; Vol. 53, No. 3. pp. 211-215.
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