Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium

Silviu Locovei, Junjie Wang, Gerhard Dahl

Research output: Contribution to journalArticle

362 Scopus citations

Abstract

The ability for long-range communication through intercellular calcium waves is inherent to cells of many tissues. A dual propagation mode for these waves includes passage of IP3 through gap junctions as well as an extracellular pathway involving ATP. The wave can be regenerative and include ATP-induced ATP release via an unknown mechanism. Here, we show that pannexin 1 channels can be activated by extracellular ATP acting through purinergic receptors of the P2Y group as well as by cytoplasmic calcium. Based on its properties, including ATP permeability, pannexin 1 may be involved in both initiation and propagation of calcium waves.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalFEBS letters
Volume580
Issue number1
DOIs
StatePublished - Jan 9 2006

Keywords

  • Activation by calcium
  • ATP-induced ATP release
  • Calcium wave
  • Pannexin
  • Purinergic receptor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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