Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium

Silviu Locovei, Junjie Wang, Gerhard Dahl

Research output: Contribution to journalArticle

351 Citations (Scopus)

Abstract

The ability for long-range communication through intercellular calcium waves is inherent to cells of many tissues. A dual propagation mode for these waves includes passage of IP3 through gap junctions as well as an extracellular pathway involving ATP. The wave can be regenerative and include ATP-induced ATP release via an unknown mechanism. Here, we show that pannexin 1 channels can be activated by extracellular ATP acting through purinergic receptors of the P2Y group as well as by cytoplasmic calcium. Based on its properties, including ATP permeability, pannexin 1 may be involved in both initiation and propagation of calcium waves.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalFEBS Letters
Volume580
Issue number1
DOIs
StatePublished - Jan 9 2006

Fingerprint

Calcium-Sensing Receptors
Cytoplasmic and Nuclear Receptors
Adenosine Triphosphate
Chemical activation
Calcium
Calcium Signaling
Purinergic P2Y Receptors
Gap Junctions
Permeability
Tissue
Communication

Keywords

  • Activation by calcium
  • ATP-induced ATP release
  • Calcium wave
  • Pannexin
  • Purinergic receptor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. / Locovei, Silviu; Wang, Junjie; Dahl, Gerhard.

In: FEBS Letters, Vol. 580, No. 1, 09.01.2006, p. 239-244.

Research output: Contribution to journalArticle

Locovei, Silviu ; Wang, Junjie ; Dahl, Gerhard. / Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. In: FEBS Letters. 2006 ; Vol. 580, No. 1. pp. 239-244.
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