Activation of NF-κB in Schwann cells is dispensable for myelination In vivo

Paul D. Morton, Anna Dellarole, Michelle H. Theus, Winston M. Walters, Summer S. Berge, John R. Bethea

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22 Scopus citations

Abstract

Peripheral myelination is a dynamic process orchestrated by axons and Schwann cells. Although the signaling mechanisms governing myelination are not fully understood, NF-κB activation in Schwann cells has been implicated as a key regulator in vitro. Using a mouse model, we show that nuclear factor κB activation in Schwann cells is not required for myelination in vivo.

Original languageEnglish (US)
Pages (from-to)9932-9936
Number of pages5
JournalJournal of Neuroscience
Volume33
Issue number24
DOIs
StatePublished - Jun 17 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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    Morton, P. D., Dellarole, A., Theus, M. H., Walters, W. M., Berge, S. S., & Bethea, J. R. (2013). Activation of NF-κB in Schwann cells is dispensable for myelination In vivo. Journal of Neuroscience, 33(24), 9932-9936. https://doi.org/10.1523/JNEUROSCI.2483-12.2013