Activation of human B lymphocytes. VII. The regulatory effect of cyclic adenosine monophosphate on human B cell activation

Paul Katz, Anthony S. Fauci

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Cyclic adenosine monophosphate (cAMP) has been demonstrated to play an integral role in the regulation of B cell activation. By employing a plaque-forming cell (PFC) assay for polyclonal activation of human B lymphocytes, it was demonstrated that dibutyryl cyclic adenosine monophosphate (DB-cAMP) markedly increased the PFC response of pokeweed mitogen (PWM)-stimulated lymphocytes. Inducers of intracellular cAMP effected a comparable enhancement. Co-cultures of fresh lymphocytes with autologous T cells which had been pre-incubated with DB-cAMP produced an enhancement of B cell activation by a selective effect on the T cells. The mechanism of action of this enhancement of the B cell response is most likely a relative increase in helper T cell function resulting from a selective inhibition of suppressor T cells.

Original languageEnglish (US)
Pages (from-to)334-338
Number of pages5
JournalThe Journal of Allergy and Clinical Immunology
Volume61
Issue number5
DOIs
StatePublished - May 1978

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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