Abstract
Cyclic adenosine monophosphate (cAMP) has been demonstrated to play an integral role in the regulation of B cell activation. By employing a plaque-forming cell (PFC) assay for polyclonal activation of human B lymphocytes, it was demonstrated that dibutyryl cyclic adenosine monophosphate (DB-cAMP) markedly increased the PFC response of pokeweed mitogen (PWM)-stimulated lymphocytes. Inducers of intracellular cAMP effected a comparable enhancement. Co-cultures of fresh lymphocytes with autologous T cells which had been pre-incubated with DB-cAMP produced an enhancement of B cell activation by a selective effect on the T cells. The mechanism of action of this enhancement of the B cell response is most likely a relative increase in helper T cell function resulting from a selective inhibition of suppressor T cells.
Original language | English (US) |
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Pages (from-to) | 334-338 |
Number of pages | 5 |
Journal | The Journal of Allergy and Clinical Immunology |
Volume | 61 |
Issue number | 5 |
DOIs | |
State | Published - May 1978 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology