Activation-induced cytidine deaminase and switched memory B cells as predictors of effective in vivo responses to the influenza vaccine

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Aging impairs humoral immune responses, leading to increased frequency and severity of infectious diseases and reduced protective effects of vaccination. We have identified B-cell biomarkers that are reduced by aging and that can be used as predictive markers of the response of an individual to vaccination. The identification of these biomarkers will have an impact on the development of effective vaccines to protect the elderly from infections and other debilitating diseases.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages107-114
Number of pages8
Volume1343
DOIs
StatePublished - 2015
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1343
ISSN (Print)10643745

Keywords

  • Activation-induced cytidine deaminase
  • Antibody vaccine response
  • Class switch recombination

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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    Frasca, D., Diaz, A., & Blomberg, B. B. (2015). Activation-induced cytidine deaminase and switched memory B cells as predictors of effective in vivo responses to the influenza vaccine. In Methods in Molecular Biology (Vol. 1343, pp. 107-114). (Methods in Molecular Biology; Vol. 1343). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-2963-4_9