Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells

Patrik Rorsman, Krister Bokvist, Carina Ämmälä, Per Arkhammar, Per Olof Berggren, Olof Larsson, Karin Wåhlander

Research output: Contribution to journalArticle

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Abstract

INSULIN is produced and secreted by the B cells in the endocrine pancreas. In vivo, insulin secretion is under the control of a number of metabolic, neural and hormonal substances. It is now clear that stimulation of insulin release by fuel secretagogues, such as glucose, involves the closure of K+ channels that are sensitive to the intracellular ATP concentration (KATP channels)1. This leads to membrane depolarization and the generation of Ca2+-dependent action potentials2. The mechanisms whereby hormones and neurotransmitters such as adrenaline, galanin and somatostatin, which are released by intraislet nerve endings and the pancreatic D cells, produce inhibition of insulin secretion are not clear3. Here we show adrenaline suppresses B-cell electrical activity (and thus insulin secretion) by a G protein-dependent mechanism, which culminates in the activation of a sulphonylurea-insensitive low-conductance K+ channel distinct from the KATP channel.

Original languageEnglish
Pages (from-to)77-79
Number of pages3
JournalNature
Volume349
Issue number6304
StatePublished - Jan 3 1991
Externally publishedYes

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Insulin-Secreting Cells
GTP-Binding Proteins
Epinephrine
Insulin
KATP Channels
B-Lymphocytes
Galanin
Somatostatin-Secreting Cells
Nerve Endings
Somatostatin
Islets of Langerhans
Neurotransmitter Agents
Adenosine Triphosphate
protein K
Hormones
Glucose
Membranes

ASJC Scopus subject areas

  • General

Cite this

Rorsman, P., Bokvist, K., Ämmälä, C., Arkhammar, P., Berggren, P. O., Larsson, O., & Wåhlander, K. (1991). Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells. Nature, 349(6304), 77-79.

Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells. / Rorsman, Patrik; Bokvist, Krister; Ämmälä, Carina; Arkhammar, Per; Berggren, Per Olof; Larsson, Olof; Wåhlander, Karin.

In: Nature, Vol. 349, No. 6304, 03.01.1991, p. 77-79.

Research output: Contribution to journalArticle

Rorsman, P, Bokvist, K, Ämmälä, C, Arkhammar, P, Berggren, PO, Larsson, O & Wåhlander, K 1991, 'Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells', Nature, vol. 349, no. 6304, pp. 77-79.
Rorsman P, Bokvist K, Ämmälä C, Arkhammar P, Berggren PO, Larsson O et al. Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells. Nature. 1991 Jan 3;349(6304):77-79.
Rorsman, Patrik ; Bokvist, Krister ; Ämmälä, Carina ; Arkhammar, Per ; Berggren, Per Olof ; Larsson, Olof ; Wåhlander, Karin. / Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells. In: Nature. 1991 ; Vol. 349, No. 6304. pp. 77-79.
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