Activating FLT3 mutations are detectable in chronic and blast phases of chronic myeloproliferative disorders other than chronic myeloid leukemia

Pei Lin, Dan Jones, L. Jeffrey Medeiros, Weina Chen, Francisco Vega, Rajyalakshmi Luthra

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

FLT3 gene mutations, either internal tandem duplication (ITD) or D835 point mutations, have been studied extensively in acute myeloid leukemia and myelodysplastic syndrome (MDS). Little is known about FLT3 mutations in chronic myeloproliferative diseases (CMPDs) or their relationship with V617F JAK2 mutations. We analyzed bone marrow samples from 142 patients with Philadelphia (Ph) chromosome- CMPD or CMPD/MDS and from 119 patients with Ph+ chronic myeloid leukemia (CML) using a multiplex polymerase chain reaction assay. FLT3 mutations, 11 ITD and 2 D835, were detected in 13 (9.2%) patients with CMPD or CMPD/MDS, 7 in blast phase and 6 in chronic phase. Analyses for JAK2 mutations in 11 of 13 cases were all negative. By contrast, no FLT3 mutations were detected in CML, including 108 chronic and 11 blast phase cases. FLT3 mutations occur in approximately 10% of CMPD and CMPD/MDS but are not observed in JAK2+ CMPD or in CML.

Original languageEnglish
Pages (from-to)530-533
Number of pages4
JournalAmerican Journal of Clinical Pathology
Volume126
Issue number4
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Fingerprint

Blast Crisis
Myeloproliferative Disorders
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Chronic Disease
Mutation
Myelodysplastic Syndromes
Philadelphia Chromosome
Multiplex Polymerase Chain Reaction
Point Mutation
Acute Myeloid Leukemia
Bone Marrow

Keywords

  • Chronic myeloproliferative disorders
  • FLT3 gene mutations

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Activating FLT3 mutations are detectable in chronic and blast phases of chronic myeloproliferative disorders other than chronic myeloid leukemia. / Lin, Pei; Jones, Dan; Medeiros, L. Jeffrey; Chen, Weina; Vega, Francisco; Luthra, Rajyalakshmi.

In: American Journal of Clinical Pathology, Vol. 126, No. 4, 01.10.2006, p. 530-533.

Research output: Contribution to journalArticle

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AU - Jones, Dan

AU - Medeiros, L. Jeffrey

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AU - Vega, Francisco

AU - Luthra, Rajyalakshmi

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