Actions of growth hormone-release inhibiting hormone (Somatostatin) on the renin aldosterone system

A. Gomez-Pan, M. H. Snow, D. A. Piercy, V. Robson, R. Wilkinson, R. Hall, D. C. Evered, G. M. Besser, A. V. Schally, A. J. Kastin, D. H. Coy

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Administration of growth hormone-release inhibiting hormone (GH-RIH, somatostatin), as a 90 minute infusion (10 ug/min), to 3 healthy young men under conditions of active renin secretion achieved by pretreatment with furosemide (80 mg daily for 5 days), caused a mean 30% fall in plasma renin activity, which returned to basal levels immediately after stopping the GH-RIH infusion. Plasma aldosterone levels were not affected during the course of this experiment.

Original languageEnglish (US)
Pages (from-to)240-243
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume43
Issue number1
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Gomez-Pan, A., Snow, M. H., Piercy, D. A., Robson, V., Wilkinson, R., Hall, R., Evered, D. C., Besser, G. M., Schally, A. V., Kastin, A. J., & Coy, D. H. (1976). Actions of growth hormone-release inhibiting hormone (Somatostatin) on the renin aldosterone system. Journal of Clinical Endocrinology and Metabolism, 43(1), 240-243. https://doi.org/10.1210/jcem-43-1-240