ACTION OF GROWTH-HORMONE-RELEASE INHIBITORY HORMONE IN HEALTHY MEN AND IN ACROMEGALY

R. Hall, A. V. Schally, D. Evered, A. J. Kastin, C. H. Mortimer, W. M.G. Tunbridge, G. M. Besser, D. H. Coy, D. J. Goldie, A. S. Mcneilly, C. Phenekos, D. Weightman

Research output: Contribution to journalArticle

218 Scopus citations

Abstract

The synthetic growth-hormone-release inhibitory hormone (G.R.-I.H.) inhibits G.H. response to insulin-induced hypoglycæmia without affecting the prolactin or corticosteroid responses, but the effects are short-lived. The normal thyrotrophin and follicle-stimulating hormone (F.S.H.) responses to thyrotrophin-releasing hormone (T.R.H.) were impaired by G.R.-I.H., although the prolactin response was unaffected. G.R.-I.H. did not alter luteinising hormone (L.H.) or F.S.H basally or after L.H/F.S.H releasing hormone. Circulating G.H. levels fell strikingly in three acromegalic patients given G.R.-I.H. infusion, but their prolactin levels were not affected. G.R.-I.H. holds great promise for the medical treatment of diseases associated with excess G.H. secretion such as acromegaly, gigantism, and diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)581-584
Number of pages4
JournalThe Lancet
Volume302
Issue number7829
DOIs
StatePublished - Sep 15 1973

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'ACTION OF GROWTH-HORMONE-RELEASE INHIBITORY HORMONE IN HEALTHY MEN AND IN ACROMEGALY'. Together they form a unique fingerprint.

  • Cite this

    Hall, R., Schally, A. V., Evered, D., Kastin, A. J., Mortimer, C. H., Tunbridge, W. M. G., Besser, G. M., Coy, D. H., Goldie, D. J., Mcneilly, A. S., Phenekos, C., & Weightman, D. (1973). ACTION OF GROWTH-HORMONE-RELEASE INHIBITORY HORMONE IN HEALTHY MEN AND IN ACROMEGALY. The Lancet, 302(7829), 581-584. https://doi.org/10.1016/S0140-6736(73)92413-6