Action of externally applied ATP on rat reticulospinal vasomotor neurons

Miao Kun Sun, Claes Wahlestedt, Donald J. Reis

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

In anesthetized rats, iontophoretic application of ATP excited the spinal cord-projection neurons in the rostral ventrolateral reticular nucleus of the medulla oblongata. The neuronal response to ATP was mimicked and then blocked by α,β-methylene-ATP, a metabolically stable ATP analogue, and the response was abolished by suramin. Microinjections of ATP (3-100 pmol) into the rostral ventrolateral medulla produced a powerful pressor response. The results suggest that ATP may function as a neurotransmitter or neuromodulator involved in medullary regulation of cardiovascular functions.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalEuropean Journal of Pharmacology
Volume224
Issue number1
DOIs
StatePublished - Nov 24 1992
Externally publishedYes

Keywords

  • ATP
  • Rostral ventrolateral medulla
  • Vasomotor neurons

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Fingerprint Dive into the research topics of 'Action of externally applied ATP on rat reticulospinal vasomotor neurons'. Together they form a unique fingerprint.

  • Cite this