Action of carbamoylating agents on the uptake of metabolites in hepatomas and liver

Michael A. Lea, Aleykutty Luke, Jennifer J. Hu, Omaida Velazquez

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The effects of 2-chloroethylisocyanate, ethylisocyanate and sodium cyanate on the uptake of isotope-labeled thymidine, leucine and H2O were compared in rat liver and hepatomas. The data suggested that carbamoylating agents may have a common property of inhibiting uptake of compounds in hepatomas under conditions in which there is a smaller effect or no action in the liver of tumorbearing rats. The distinction between tissues may have been mediated, in part, through effects on tumor circulation and was less apparent when isolated cells were studied in vitro. Preferential inhibitory effects of carbamoylating agents on the uptake of leucine and H2O were also observed with a murine hepatoma, but they were not as great as with rat hepatomas.

Original languageEnglish (US)
Pages (from-to)2775-2781
Number of pages7
JournalBiochemical Pharmacology
Volume36
Issue number17
DOIs
StatePublished - Sep 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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