TY - JOUR
T1 - Actin up
T2 - regulation of podocyte structure and function by components of the actin cytoskeleton
AU - Faul, Christian
AU - Asanuma, Katsuhiko
AU - Yanagida-Asanuma, Etsuko
AU - Kim, Kwanghee
AU - Mundel, Peter
N1 - Funding Information:
P.M. is supported by NIH grants DA18886, DK57683, DK062472 and the George M. O’Brien Kidney Center DK064236; K.A. is supported by the Mochida Memorial Foundation, Naioto Foundation, Ichiro Kanehara Foundation and Uehara Memorial Foundation.
PY - 2007/9
Y1 - 2007/9
N2 - Podocytes of the renal glomerulus are unique cells with a complex cellular organization consisting of a cell body, major processes and foot processes. Podocyte foot processes form a characteristic interdigitating pattern with foot processes of neighboring podocytes, leaving in between the filtration slits that are bridged by the glomerular slit diaphragm. The highly dynamic foot processes contain an actin-based contractile apparatus comparable to that of smooth muscle cells or pericytes. Mutations affecting several podocyte proteins lead to rearrangement of the actin cytoskeleton, disruption of the filtration barrier and subsequent renal disease. The fact that the dynamic regulation of the podocyte cytoskeleton is vital to kidney function has led to podocytes emerging as an excellent model system for studying actin cytoskeleton dynamics in a physiological context.
AB - Podocytes of the renal glomerulus are unique cells with a complex cellular organization consisting of a cell body, major processes and foot processes. Podocyte foot processes form a characteristic interdigitating pattern with foot processes of neighboring podocytes, leaving in between the filtration slits that are bridged by the glomerular slit diaphragm. The highly dynamic foot processes contain an actin-based contractile apparatus comparable to that of smooth muscle cells or pericytes. Mutations affecting several podocyte proteins lead to rearrangement of the actin cytoskeleton, disruption of the filtration barrier and subsequent renal disease. The fact that the dynamic regulation of the podocyte cytoskeleton is vital to kidney function has led to podocytes emerging as an excellent model system for studying actin cytoskeleton dynamics in a physiological context.
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U2 - 10.1016/j.tcb.2007.06.006
DO - 10.1016/j.tcb.2007.06.006
M3 - Review article
C2 - 17804239
AN - SCOPUS:34848907421
VL - 17
SP - 428
EP - 437
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 9
ER -