Abstract
Podocytes of the renal glomerulus are unique cells with a complex cellular organization consisting of a cell body, major processes and foot processes. Podocyte foot processes form a characteristic interdigitating pattern with foot processes of neighboring podocytes, leaving in between the filtration slits that are bridged by the glomerular slit diaphragm. The highly dynamic foot processes contain an actin-based contractile apparatus comparable to that of smooth muscle cells or pericytes. Mutations affecting several podocyte proteins lead to rearrangement of the actin cytoskeleton, disruption of the filtration barrier and subsequent renal disease. The fact that the dynamic regulation of the podocyte cytoskeleton is vital to kidney function has led to podocytes emerging as an excellent model system for studying actin cytoskeleton dynamics in a physiological context.
| Original language | English |
|---|---|
| Pages (from-to) | 428-437 |
| Number of pages | 10 |
| Journal | Trends in Cell Biology |
| Volume | 17 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Actin up : regulation of podocyte structure and function by components of the actin cytoskeleton. / Faul, Christian H; Asanuma, Katsuhiko; Yanagida-Asanuma, Etsuko; Kim, Kwanghee; Mundel, Peter.
In: Trends in Cell Biology, Vol. 17, No. 9, 01.09.2007, p. 428-437.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Actin up
T2 - regulation of podocyte structure and function by components of the actin cytoskeleton
AU - Faul, Christian H
AU - Asanuma, Katsuhiko
AU - Yanagida-Asanuma, Etsuko
AU - Kim, Kwanghee
AU - Mundel, Peter
PY - 2007/9/1
Y1 - 2007/9/1
N2 - Podocytes of the renal glomerulus are unique cells with a complex cellular organization consisting of a cell body, major processes and foot processes. Podocyte foot processes form a characteristic interdigitating pattern with foot processes of neighboring podocytes, leaving in between the filtration slits that are bridged by the glomerular slit diaphragm. The highly dynamic foot processes contain an actin-based contractile apparatus comparable to that of smooth muscle cells or pericytes. Mutations affecting several podocyte proteins lead to rearrangement of the actin cytoskeleton, disruption of the filtration barrier and subsequent renal disease. The fact that the dynamic regulation of the podocyte cytoskeleton is vital to kidney function has led to podocytes emerging as an excellent model system for studying actin cytoskeleton dynamics in a physiological context.
AB - Podocytes of the renal glomerulus are unique cells with a complex cellular organization consisting of a cell body, major processes and foot processes. Podocyte foot processes form a characteristic interdigitating pattern with foot processes of neighboring podocytes, leaving in between the filtration slits that are bridged by the glomerular slit diaphragm. The highly dynamic foot processes contain an actin-based contractile apparatus comparable to that of smooth muscle cells or pericytes. Mutations affecting several podocyte proteins lead to rearrangement of the actin cytoskeleton, disruption of the filtration barrier and subsequent renal disease. The fact that the dynamic regulation of the podocyte cytoskeleton is vital to kidney function has led to podocytes emerging as an excellent model system for studying actin cytoskeleton dynamics in a physiological context.
UR - http://www.scopus.com/inward/record.url?scp=34848907421&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34848907421&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2007.06.006
DO - 10.1016/j.tcb.2007.06.006
M3 - Article
C2 - 17804239
AN - SCOPUS:34848907421
VL - 17
SP - 428
EP - 437
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 9
ER -