Acral melanocytic lesions in the United States: Prevalence, awareness, and dermoscopic patterns in skin-of-color and non-Hispanic white patients

Reshmi Madankumar, Priyanka V. Gumaste, Kathryn Martires, Panta R. Schaffer, Sonal Choudhary, Leyre Falto-Aizpurua, Harleen Arora, Penelope J. Kallis, Shailee Patel, Shadi Damanpour, Margaret I. Sanchez, Natalie Yin, Aegean Chan, Miguel Sanchez, David Polsky, Holly Kanavy, James M. Grichnik, Jennifer A. Stein

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background Acral lentiginous melanoma has increased mortality compared with other melanoma subtypes and disproportionately affects ethnic minorities. Acral melanocytic lesions have not been well studied in diverse populations of the United States. Objective We sought to assess the prevalence, awareness, and dermoscopic patterns of acral melanocytic lesions in skin-of-color and non-Hispanic white patients. Methods We prospectively examined the palms and soles of 1052 patients presenting to dermatology clinics in New York, NY, and Miami, FL, from October 2013 to April 2015. Results Acral melanocytic lesions were observed in 36% of our cohort. Skin-of-color patients were more likely to have acral melanocytic lesions than non-Hispanic white patients (P <.01). Acral melanocytic lesions correlated with increased mole counts, particularly on non-Hispanic white patients. The majority of lesions demonstrated benign dermoscopic patterns. We observed 2 lesions with the parallel ridge pattern in our cohort, both found to be atypical nevi on biopsy specimen. Patients often lacked awareness of the presence of their lesions. Limitations Interobserver variability in assessing dermoscopic patterns is a limitation. Conclusions Melanocytic lesions of the palms and soles are common, particularly in a cohort of multiple ethnicities from the United States. Dermoscopy of acral lesions is an important clinical tool for diagnosis and management of these lesions.

Original languageEnglish (US)
Pages (from-to)724-730.e1
JournalJournal of the American Academy of Dermatology
Volume74
Issue number4
DOIs
StatePublished - Apr 1 2016

Keywords

  • acquired acral nevi
  • acral lentiginous melanoma
  • acral melanocytic lesions
  • acral pigmented lesions
  • dermoscopy
  • skin of color

ASJC Scopus subject areas

  • Dermatology

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