ACR Appropriateness Criteria®: Single Brain Metastasis

John H. Suh, Gregory M.M. Videtic, Amr M. Aref, Isabelle Germano, Brian J. Goldsmith, Joseph P. Imperato, Karen J. Marcus, Michael W. McDermott, Mark W. McDonald, Roy A. Patchell, H. Ian Robins, C. Leland Rogers, Aaron H. Wolfson, Franz J. Wippold, Laurie E. Gaspar

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Single brain metastasis represents a common neurologic complication of cancer. Given the number of treatment options that are available for patients with brain metastasis and the strong opinions that are associated with each option, appropriate treatment for these patients has become controversial. Prognostic factors such as recursive partitioning analysis and graded prognostic assessment can help guide treatment decisions. Surgery, whole brain radiation therapy (WBRT), stereotactic radiosurgery or combination of these treatments can be considered based on a number of factors. Despite Class I evidence suggestive of best therapy, the treatment recommendation is quite varied among physicians as demonstrated by the American College of Radiology's Appropriateness Panel on single brain metastasis. Given the potential concerns of the neurocognitive effects of WBRT, the use of SRS alone or SRS to a resection cavity has gained support. Since aggressive local therapy is beneficial for survival, local control and quality of life, the use of these various treatment modalities needs to be carefully investigated given the growing number of long-term survivors. Enrollment of patients onto clinical trials is important to advance our understanding of brain metastasis.

Original languageEnglish (US)
Pages (from-to)162-174
Number of pages13
JournalCurrent Problems in Cancer
Issue number3
StatePublished - May 2010
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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