Acquired peripapillary changes and progression in glaucoma

Edward J. Rockwood, Douglas R. Anderson

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


In a review of fundus photographs, changes in the degree of depigmentation or atrophy of the retinal pigment epithelium (RPE) were observed near the disc over time in 21% of cases with progressive glaucomatous cupping, but they also occurred as a natural phenomenon over time in 4% of eyes with nonprogressive glaucoma and in 3% of nonglaucomatous eyes. Thus, the peripapillary RPE shows some progressive alteration in normal individuals, but also may sometimes suffer along with the axons during glaucomatous damage. The acquired changes observed in the progressive glaucomatous eyes seem too small and too infrequent to account for the high prevalence of large haloes and crescents seen around the optic disc in glaucoma.

Original languageEnglish (US)
Pages (from-to)510-515
Number of pages6
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number6
StatePublished - Nov 1988

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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