Acquired Immunodeficiency Syndrome in Infants

Gwendolyn B. Scott, Billy E. Buck, Joni G. Leterman, Frederick L. Bloom, Wade P. Parks

Research output: Contribution to journalArticle

303 Scopus citations

Abstract

Fourteen infants with clinical and laboratory features of an acquired immunodeficiency syndrome were identified in a single metropolitan area from November 1980 to July 1983. Patients were predominantly of Haitian parentage, although two cases occurred in offspring of non-Haitian intravenous drug abusers. Only one patient had received a blood transfusion before the development of clinical findings. The predominant clinical findings included failure to thrive, persistent infection of the oral mucosa by Candida albicans, chronic pulmonary infiltrates, hepatosplenomegaly, lymphadenopathy, and diarrhea. Immunologic studies showed most of the infants to have inverted ratios of T-cells subsets, greatly increased immunoglobulin levels, and circulation immune complexes. Lymphopenia was not common, as it is in adult patients. Infectious agents responsible for opportunistic infection in this series included Pneumocystis carinii, herpesviruses, particularly cytomegalovirus, and C. albicans. Bacterial infection were common, and gram-negative sepsis was the major cause of death in the seven infants who have died. At autopsy, two infants had disseminated lymphadenopathic Kaposi's sarcoma. These observations suggest the likelihood of transplacental, perinatal, or postnatal transmission of an as yet unidentified infectious agent that causes this disease.

Original languageEnglish (US)
Pages (from-to)76-81
Number of pages6
JournalNew England Journal of Medicine
Volume310
Issue number2
DOIs
StatePublished - Jan 12 1984

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Scott, G. B., Buck, B. E., Leterman, J. G., Bloom, F. L., & Parks, W. P. (1984). Acquired Immunodeficiency Syndrome in Infants. New England Journal of Medicine, 310(2), 76-81. https://doi.org/10.1056/NEJM198401123100202