Acquired hepatocerebral degeneration in a patient with HCV cirrhosis

Complete resolution with subsequent recurrence after liver transplantation

Luis Servin-Abad, Andreas Tzakis, Eugene R Schiff, Arie Regev

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Acquired (non-wilsonian) hepatocerebral degeneration (AHID) is a chronic brain disorder caused by liver dysfunction and long-standing portal-systemic shunting. It typically presents with dysathria, ataxia, tremor, involuntary movements and altered mental status, and often does not respond to conventional medical therapy for hepatic encephalopathy. There is scarce and conflicting information regarding the clinical course of AHD after liver transplantation (OLT). We present a case of a 47-year-old woman with hepatitis C (HCV) cirrhosis who developed severe manifestations of AHD after multiple bouts of hepatic encephalopathy. Her first OLT was complicated with primary nonfunction requiring immediate retransplantation. The second OLT led to complete clinical and radiological resolution of the AHD. However the patient developed recurrence of AHD 11 months post-transplant due to recurrent HCV and chronic rejection leading to cirrhosis of the graft. The patient developed severe neurological symptoms, despite mild synthetic graft dysfunction. A third OLT led again to disappearance of the clinical and radiological manifestations of AHD. AHD may show complete resolution after OLT; however it may rapidly recur following recurrent liver disease or graft dysfunction

Original languageEnglish
Pages (from-to)1161-1165
Number of pages5
JournalLiver Transplantation
Volume12
Issue number7
DOIs
StatePublished - Jul 1 2006

Fingerprint

Hepatolenticular Degeneration
Liver Transplantation
Fibrosis
Transplants
Recurrence
Hepatic Encephalopathy
Liver Diseases
Dyskinesias
Brain Diseases
Tremor
Ataxia
Hepatitis C
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Acquired hepatocerebral degeneration in a patient with HCV cirrhosis : Complete resolution with subsequent recurrence after liver transplantation. / Servin-Abad, Luis; Tzakis, Andreas; Schiff, Eugene R; Regev, Arie.

In: Liver Transplantation, Vol. 12, No. 7, 01.07.2006, p. 1161-1165.

Research output: Contribution to journalArticle

@article{2aa9565c932c4fa5965240e8c8a3f79b,
title = "Acquired hepatocerebral degeneration in a patient with HCV cirrhosis: Complete resolution with subsequent recurrence after liver transplantation",
abstract = "Acquired (non-wilsonian) hepatocerebral degeneration (AHID) is a chronic brain disorder caused by liver dysfunction and long-standing portal-systemic shunting. It typically presents with dysathria, ataxia, tremor, involuntary movements and altered mental status, and often does not respond to conventional medical therapy for hepatic encephalopathy. There is scarce and conflicting information regarding the clinical course of AHD after liver transplantation (OLT). We present a case of a 47-year-old woman with hepatitis C (HCV) cirrhosis who developed severe manifestations of AHD after multiple bouts of hepatic encephalopathy. Her first OLT was complicated with primary nonfunction requiring immediate retransplantation. The second OLT led to complete clinical and radiological resolution of the AHD. However the patient developed recurrence of AHD 11 months post-transplant due to recurrent HCV and chronic rejection leading to cirrhosis of the graft. The patient developed severe neurological symptoms, despite mild synthetic graft dysfunction. A third OLT led again to disappearance of the clinical and radiological manifestations of AHD. AHD may show complete resolution after OLT; however it may rapidly recur following recurrent liver disease or graft dysfunction",
author = "Luis Servin-Abad and Andreas Tzakis and Schiff, {Eugene R} and Arie Regev",
year = "2006",
month = "7",
day = "1",
doi = "10.1002/lt.20815",
language = "English",
volume = "12",
pages = "1161--1165",
journal = "Liver Transplantation",
issn = "1527-6465",
publisher = "John Wiley and Sons Ltd",
number = "7",

}

TY - JOUR

T1 - Acquired hepatocerebral degeneration in a patient with HCV cirrhosis

T2 - Complete resolution with subsequent recurrence after liver transplantation

AU - Servin-Abad, Luis

AU - Tzakis, Andreas

AU - Schiff, Eugene R

AU - Regev, Arie

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Acquired (non-wilsonian) hepatocerebral degeneration (AHID) is a chronic brain disorder caused by liver dysfunction and long-standing portal-systemic shunting. It typically presents with dysathria, ataxia, tremor, involuntary movements and altered mental status, and often does not respond to conventional medical therapy for hepatic encephalopathy. There is scarce and conflicting information regarding the clinical course of AHD after liver transplantation (OLT). We present a case of a 47-year-old woman with hepatitis C (HCV) cirrhosis who developed severe manifestations of AHD after multiple bouts of hepatic encephalopathy. Her first OLT was complicated with primary nonfunction requiring immediate retransplantation. The second OLT led to complete clinical and radiological resolution of the AHD. However the patient developed recurrence of AHD 11 months post-transplant due to recurrent HCV and chronic rejection leading to cirrhosis of the graft. The patient developed severe neurological symptoms, despite mild synthetic graft dysfunction. A third OLT led again to disappearance of the clinical and radiological manifestations of AHD. AHD may show complete resolution after OLT; however it may rapidly recur following recurrent liver disease or graft dysfunction

AB - Acquired (non-wilsonian) hepatocerebral degeneration (AHID) is a chronic brain disorder caused by liver dysfunction and long-standing portal-systemic shunting. It typically presents with dysathria, ataxia, tremor, involuntary movements and altered mental status, and often does not respond to conventional medical therapy for hepatic encephalopathy. There is scarce and conflicting information regarding the clinical course of AHD after liver transplantation (OLT). We present a case of a 47-year-old woman with hepatitis C (HCV) cirrhosis who developed severe manifestations of AHD after multiple bouts of hepatic encephalopathy. Her first OLT was complicated with primary nonfunction requiring immediate retransplantation. The second OLT led to complete clinical and radiological resolution of the AHD. However the patient developed recurrence of AHD 11 months post-transplant due to recurrent HCV and chronic rejection leading to cirrhosis of the graft. The patient developed severe neurological symptoms, despite mild synthetic graft dysfunction. A third OLT led again to disappearance of the clinical and radiological manifestations of AHD. AHD may show complete resolution after OLT; however it may rapidly recur following recurrent liver disease or graft dysfunction

UR - http://www.scopus.com/inward/record.url?scp=33746012929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746012929&partnerID=8YFLogxK

U2 - 10.1002/lt.20815

DO - 10.1002/lt.20815

M3 - Article

VL - 12

SP - 1161

EP - 1165

JO - Liver Transplantation

JF - Liver Transplantation

SN - 1527-6465

IS - 7

ER -