Acoustic Analysis of a Mechanical Circulatory Support

Laila Hubbert, Per Sundbom, Matthias Loebe, Bengt Peterzén, Hans Granfeldt, Henrik Ahn

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Mechanical circulatory support technology is continually improving. However, adverse complications do occur with devastating consequences, for example, pump thrombosis that may develop in several parts of the pump system. The aim of this study was to design an experimental clot/thrombosis model to register and analyze acoustic signals from the left ventricular assist device (LVAD) HeartMate II (HMII) (Thoratec Corporation, Inc., Pleasanton, CA, USA) and detect changes in sound signals correlating to clots in the inflow, outflow, and pump housing. Using modern telecom techniques, it was possible to register and analyze the HMII pump-specific acoustic fingerprint in an experimental model of LVAD support using a mock loop. Increase in pump speed significantly (P<0.005) changed the acoustic fingerprint at certain frequency (0-23000Hz) intervals (regions: R1-3 and peaks: P1,3-4). When the ball valves connected to the tubing were narrowed sequentially by ~50% of the inner diameter (to mimic clot in the out- and inflow tubing), the frequency spectrum changed significantly (P<0.005) in P1 and P2 and R1 when the outflow tubing was narrowed. This change was not seen to the same extent when the lumen of the ball valve connected to the inflow tube was narrowed by ~50%. More significant (P<0.005) acoustic changes were detected in P1 and P2 and R1 and R3, with the largest dB figs. in the lower frequency ranges in R1 and P2, when artificial clots and blood clots passed through the pump system. At higher frequencies, a significant change in dB figs. in R3 and P4 was detected when clots passed through the pump system. Acoustic monitoring of pump sounds may become a valuable tool in LVAD surveillance.

Original languageEnglish (US)
Pages (from-to)593-598
Number of pages6
JournalArtificial Organs
Volume38
Issue number7
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Acoustics
Heart-Assist Devices
Pumps
Left ventricular assist devices
Ficus
Thrombosis
Dermatoglyphics
Tubing
Blood Substitutes
Acoustic waves
Research Design
Theoretical Models
Technology
Design of experiments
Blood
Monitoring
Industry

Keywords

  • Frequency analysis
  • Mechanical circulatory support
  • Thrombosis

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)
  • Medicine(all)

Cite this

Hubbert, L., Sundbom, P., Loebe, M., Peterzén, B., Granfeldt, H., & Ahn, H. (2014). Acoustic Analysis of a Mechanical Circulatory Support. Artificial Organs, 38(7), 593-598. https://doi.org/10.1111/aor.12244

Acoustic Analysis of a Mechanical Circulatory Support. / Hubbert, Laila; Sundbom, Per; Loebe, Matthias; Peterzén, Bengt; Granfeldt, Hans; Ahn, Henrik.

In: Artificial Organs, Vol. 38, No. 7, 2014, p. 593-598.

Research output: Contribution to journalArticle

Hubbert, L, Sundbom, P, Loebe, M, Peterzén, B, Granfeldt, H & Ahn, H 2014, 'Acoustic Analysis of a Mechanical Circulatory Support', Artificial Organs, vol. 38, no. 7, pp. 593-598. https://doi.org/10.1111/aor.12244
Hubbert L, Sundbom P, Loebe M, Peterzén B, Granfeldt H, Ahn H. Acoustic Analysis of a Mechanical Circulatory Support. Artificial Organs. 2014;38(7):593-598. https://doi.org/10.1111/aor.12244
Hubbert, Laila ; Sundbom, Per ; Loebe, Matthias ; Peterzén, Bengt ; Granfeldt, Hans ; Ahn, Henrik. / Acoustic Analysis of a Mechanical Circulatory Support. In: Artificial Organs. 2014 ; Vol. 38, No. 7. pp. 593-598.
@article{200266733bcc4cca8ea6e17a9c88875c,
title = "Acoustic Analysis of a Mechanical Circulatory Support",
abstract = "Mechanical circulatory support technology is continually improving. However, adverse complications do occur with devastating consequences, for example, pump thrombosis that may develop in several parts of the pump system. The aim of this study was to design an experimental clot/thrombosis model to register and analyze acoustic signals from the left ventricular assist device (LVAD) HeartMate II (HMII) (Thoratec Corporation, Inc., Pleasanton, CA, USA) and detect changes in sound signals correlating to clots in the inflow, outflow, and pump housing. Using modern telecom techniques, it was possible to register and analyze the HMII pump-specific acoustic fingerprint in an experimental model of LVAD support using a mock loop. Increase in pump speed significantly (P<0.005) changed the acoustic fingerprint at certain frequency (0-23000Hz) intervals (regions: R1-3 and peaks: P1,3-4). When the ball valves connected to the tubing were narrowed sequentially by ~50{\%} of the inner diameter (to mimic clot in the out- and inflow tubing), the frequency spectrum changed significantly (P<0.005) in P1 and P2 and R1 when the outflow tubing was narrowed. This change was not seen to the same extent when the lumen of the ball valve connected to the inflow tube was narrowed by ~50{\%}. More significant (P<0.005) acoustic changes were detected in P1 and P2 and R1 and R3, with the largest dB figs. in the lower frequency ranges in R1 and P2, when artificial clots and blood clots passed through the pump system. At higher frequencies, a significant change in dB figs. in R3 and P4 was detected when clots passed through the pump system. Acoustic monitoring of pump sounds may become a valuable tool in LVAD surveillance.",
keywords = "Frequency analysis, Mechanical circulatory support, Thrombosis",
author = "Laila Hubbert and Per Sundbom and Matthias Loebe and Bengt Peterz{\'e}n and Hans Granfeldt and Henrik Ahn",
year = "2014",
doi = "10.1111/aor.12244",
language = "English (US)",
volume = "38",
pages = "593--598",
journal = "Artificial Organs",
issn = "0160-564X",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Acoustic Analysis of a Mechanical Circulatory Support

AU - Hubbert, Laila

AU - Sundbom, Per

AU - Loebe, Matthias

AU - Peterzén, Bengt

AU - Granfeldt, Hans

AU - Ahn, Henrik

PY - 2014

Y1 - 2014

N2 - Mechanical circulatory support technology is continually improving. However, adverse complications do occur with devastating consequences, for example, pump thrombosis that may develop in several parts of the pump system. The aim of this study was to design an experimental clot/thrombosis model to register and analyze acoustic signals from the left ventricular assist device (LVAD) HeartMate II (HMII) (Thoratec Corporation, Inc., Pleasanton, CA, USA) and detect changes in sound signals correlating to clots in the inflow, outflow, and pump housing. Using modern telecom techniques, it was possible to register and analyze the HMII pump-specific acoustic fingerprint in an experimental model of LVAD support using a mock loop. Increase in pump speed significantly (P<0.005) changed the acoustic fingerprint at certain frequency (0-23000Hz) intervals (regions: R1-3 and peaks: P1,3-4). When the ball valves connected to the tubing were narrowed sequentially by ~50% of the inner diameter (to mimic clot in the out- and inflow tubing), the frequency spectrum changed significantly (P<0.005) in P1 and P2 and R1 when the outflow tubing was narrowed. This change was not seen to the same extent when the lumen of the ball valve connected to the inflow tube was narrowed by ~50%. More significant (P<0.005) acoustic changes were detected in P1 and P2 and R1 and R3, with the largest dB figs. in the lower frequency ranges in R1 and P2, when artificial clots and blood clots passed through the pump system. At higher frequencies, a significant change in dB figs. in R3 and P4 was detected when clots passed through the pump system. Acoustic monitoring of pump sounds may become a valuable tool in LVAD surveillance.

AB - Mechanical circulatory support technology is continually improving. However, adverse complications do occur with devastating consequences, for example, pump thrombosis that may develop in several parts of the pump system. The aim of this study was to design an experimental clot/thrombosis model to register and analyze acoustic signals from the left ventricular assist device (LVAD) HeartMate II (HMII) (Thoratec Corporation, Inc., Pleasanton, CA, USA) and detect changes in sound signals correlating to clots in the inflow, outflow, and pump housing. Using modern telecom techniques, it was possible to register and analyze the HMII pump-specific acoustic fingerprint in an experimental model of LVAD support using a mock loop. Increase in pump speed significantly (P<0.005) changed the acoustic fingerprint at certain frequency (0-23000Hz) intervals (regions: R1-3 and peaks: P1,3-4). When the ball valves connected to the tubing were narrowed sequentially by ~50% of the inner diameter (to mimic clot in the out- and inflow tubing), the frequency spectrum changed significantly (P<0.005) in P1 and P2 and R1 when the outflow tubing was narrowed. This change was not seen to the same extent when the lumen of the ball valve connected to the inflow tube was narrowed by ~50%. More significant (P<0.005) acoustic changes were detected in P1 and P2 and R1 and R3, with the largest dB figs. in the lower frequency ranges in R1 and P2, when artificial clots and blood clots passed through the pump system. At higher frequencies, a significant change in dB figs. in R3 and P4 was detected when clots passed through the pump system. Acoustic monitoring of pump sounds may become a valuable tool in LVAD surveillance.

KW - Frequency analysis

KW - Mechanical circulatory support

KW - Thrombosis

UR - http://www.scopus.com/inward/record.url?scp=84904393524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904393524&partnerID=8YFLogxK

U2 - 10.1111/aor.12244

DO - 10.1111/aor.12244

M3 - Article

C2 - 24372095

AN - SCOPUS:84904393524

VL - 38

SP - 593

EP - 598

JO - Artificial Organs

JF - Artificial Organs

SN - 0160-564X

IS - 7

ER -