Acid ceramidase inhibition: A novel target for cancer therapy

Xiang Liu, Saeed Elojeimy, Lorianne S. Turner, Ayman E.M. Mahdy, Youssef H. Zeidan, Alicja Bielawska, Jacek Bielawski, Jian Yun Dong, Ahmed M. El-Zawahry, Gui Wen Guo, Yusuf A. Hannun, David H. Holman, Semyon Rubinchik, Zdzislaw Szulc, Thomas E. Keane, Mahvash Tavassoli, James S. Norris

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

During the last decade, sphingolipid deregulation, namely the balance between the pro-apoptotic molecule ceramide and the anti-apoptotic sphingolipid sphingosine-1-phosphate, has emerged as an important factor in cancer pathology and resistance to therapy. Thus, our research has been focused on developing drugs that are able to restore normal sphingolipid balance, precisely through increasing the levels of ceramide and decreasing sphingosine-1-phosphate. Particularly, inhibition of the ceramide metabolizing enzyme acid ceramidase, whose overexpression in cancer cells has been implicated in resistance to treatment, is proving to be an efficient and promising strategy. In this review, we consider our recent work with acid ceramidase inhibitors, in combination with radiation or gene therapy as a sensitizer that enhance cancer therapy.

Original languageEnglish (US)
Pages (from-to)2293-2298
Number of pages6
JournalFrontiers in Bioscience
Volume13
Issue number6
DOIs
StatePublished - May 1 2008

    Fingerprint

Keywords

  • Acid ceramidase
  • Gene therapy
  • Review
  • Sphingolipids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Liu, X., Elojeimy, S., Turner, L. S., Mahdy, A. E. M., Zeidan, Y. H., Bielawska, A., Bielawski, J., Dong, J. Y., El-Zawahry, A. M., Guo, G. W., Hannun, Y. A., Holman, D. H., Rubinchik, S., Szulc, Z., Keane, T. E., Tavassoli, M., & Norris, J. S. (2008). Acid ceramidase inhibition: A novel target for cancer therapy. Frontiers in Bioscience, 13(6), 2293-2298. https://doi.org/10.2741/2843