Acetylsalicylic acid-silicone oil suspension for proliferative vitreoretinopathie: First results of Austrian clinical multicentre study

M. T. Kralinger, U. Stolba, M. Velikay, S. Egger, S. Binder, A. Wedrich, A. Haas, Jean-Marie A Parel, G. F. Kieselbach

Research output: Contribution to journalArticle

Abstract

Background: A new surgical method of intravitreal tamponade with silicone oil suspended with acetylsalicylic acid (AS) was investigated for safety and efficiency in the treatment of proliferative vitreoretinopathie. The study was designed as a prospective randomized, controlled double-blind Multicentre Study. Methods: A standard three-port pars plana vitrectomy was performed in 29 eyes of 29 patients. In case a natural lens was present simultaneous phacoemulsification was obligatory. The control group received standard therapy vitreous tamponade with pure 5000centistoke silicone oil while the silicone oil was suspended with AS to a concentration of 0.2mg/ml in the study group. After 6 months follow up the tamponade was removed in all eyes. Results: The safety of AS SiO could be demonstrated: the AS SiO was well tolerated and stayed clear during the study period of 6 months. The clinical examination revealed no signs of local or systemic adverse effects in the study eyes. The visual acuities were well matched before inclusion into the study and there was no evidence of significant differences during the follow up period and in final visual outcome between the two groups. The rate of redetachments defined as the primary outcome parameter was the same for both groups. Conclusions: Acetylsalicylic acid delivery by intravitreal silicone oil in the human eye was shown a safe method that may offer a delivery route for other antiproliferative agents into the posterior pole.

Original languageEnglish
Pages (from-to)218-220
Number of pages3
JournalSpektrum der Augenheilkunde
Volume21
Issue number4
DOIs
StatePublished - Nov 21 2007

Fingerprint

Silicone Oils
Aspirin
Multicenter Studies
Suspensions
Safety
Phacoemulsification
Temazepam
Vitrectomy
Double-Blind Method
Lenses
Visual Acuity
Clinical Studies
Control Groups
Therapeutics

Keywords

  • Acetylsalicylic acid-silicone oil suspension
  • Efficiency
  • Proliferative vitreoretinopathie
  • PVR
  • Safety

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Acetylsalicylic acid-silicone oil suspension for proliferative vitreoretinopathie : First results of Austrian clinical multicentre study. / Kralinger, M. T.; Stolba, U.; Velikay, M.; Egger, S.; Binder, S.; Wedrich, A.; Haas, A.; Parel, Jean-Marie A; Kieselbach, G. F.

In: Spektrum der Augenheilkunde, Vol. 21, No. 4, 21.11.2007, p. 218-220.

Research output: Contribution to journalArticle

Kralinger, M. T. ; Stolba, U. ; Velikay, M. ; Egger, S. ; Binder, S. ; Wedrich, A. ; Haas, A. ; Parel, Jean-Marie A ; Kieselbach, G. F. / Acetylsalicylic acid-silicone oil suspension for proliferative vitreoretinopathie : First results of Austrian clinical multicentre study. In: Spektrum der Augenheilkunde. 2007 ; Vol. 21, No. 4. pp. 218-220.
@article{3dd5bec32686482e9a54bb95fb78e949,
title = "Acetylsalicylic acid-silicone oil suspension for proliferative vitreoretinopathie: First results of Austrian clinical multicentre study",
abstract = "Background: A new surgical method of intravitreal tamponade with silicone oil suspended with acetylsalicylic acid (AS) was investigated for safety and efficiency in the treatment of proliferative vitreoretinopathie. The study was designed as a prospective randomized, controlled double-blind Multicentre Study. Methods: A standard three-port pars plana vitrectomy was performed in 29 eyes of 29 patients. In case a natural lens was present simultaneous phacoemulsification was obligatory. The control group received standard therapy vitreous tamponade with pure 5000centistoke silicone oil while the silicone oil was suspended with AS to a concentration of 0.2mg/ml in the study group. After 6 months follow up the tamponade was removed in all eyes. Results: The safety of AS SiO could be demonstrated: the AS SiO was well tolerated and stayed clear during the study period of 6 months. The clinical examination revealed no signs of local or systemic adverse effects in the study eyes. The visual acuities were well matched before inclusion into the study and there was no evidence of significant differences during the follow up period and in final visual outcome between the two groups. The rate of redetachments defined as the primary outcome parameter was the same for both groups. Conclusions: Acetylsalicylic acid delivery by intravitreal silicone oil in the human eye was shown a safe method that may offer a delivery route for other antiproliferative agents into the posterior pole.",
keywords = "Acetylsalicylic acid-silicone oil suspension, Efficiency, Proliferative vitreoretinopathie, PVR, Safety",
author = "Kralinger, {M. T.} and U. Stolba and M. Velikay and S. Egger and S. Binder and A. Wedrich and A. Haas and Parel, {Jean-Marie A} and Kieselbach, {G. F.}",
year = "2007",
month = "11",
day = "21",
doi = "10.1007/s00717-007-0214-0",
language = "English",
volume = "21",
pages = "218--220",
journal = "Spektrum der Augenheilkunde",
issn = "0930-4282",
publisher = "Springer Wien",
number = "4",

}

TY - JOUR

T1 - Acetylsalicylic acid-silicone oil suspension for proliferative vitreoretinopathie

T2 - First results of Austrian clinical multicentre study

AU - Kralinger, M. T.

AU - Stolba, U.

AU - Velikay, M.

AU - Egger, S.

AU - Binder, S.

AU - Wedrich, A.

AU - Haas, A.

AU - Parel, Jean-Marie A

AU - Kieselbach, G. F.

PY - 2007/11/21

Y1 - 2007/11/21

N2 - Background: A new surgical method of intravitreal tamponade with silicone oil suspended with acetylsalicylic acid (AS) was investigated for safety and efficiency in the treatment of proliferative vitreoretinopathie. The study was designed as a prospective randomized, controlled double-blind Multicentre Study. Methods: A standard three-port pars plana vitrectomy was performed in 29 eyes of 29 patients. In case a natural lens was present simultaneous phacoemulsification was obligatory. The control group received standard therapy vitreous tamponade with pure 5000centistoke silicone oil while the silicone oil was suspended with AS to a concentration of 0.2mg/ml in the study group. After 6 months follow up the tamponade was removed in all eyes. Results: The safety of AS SiO could be demonstrated: the AS SiO was well tolerated and stayed clear during the study period of 6 months. The clinical examination revealed no signs of local or systemic adverse effects in the study eyes. The visual acuities were well matched before inclusion into the study and there was no evidence of significant differences during the follow up period and in final visual outcome between the two groups. The rate of redetachments defined as the primary outcome parameter was the same for both groups. Conclusions: Acetylsalicylic acid delivery by intravitreal silicone oil in the human eye was shown a safe method that may offer a delivery route for other antiproliferative agents into the posterior pole.

AB - Background: A new surgical method of intravitreal tamponade with silicone oil suspended with acetylsalicylic acid (AS) was investigated for safety and efficiency in the treatment of proliferative vitreoretinopathie. The study was designed as a prospective randomized, controlled double-blind Multicentre Study. Methods: A standard three-port pars plana vitrectomy was performed in 29 eyes of 29 patients. In case a natural lens was present simultaneous phacoemulsification was obligatory. The control group received standard therapy vitreous tamponade with pure 5000centistoke silicone oil while the silicone oil was suspended with AS to a concentration of 0.2mg/ml in the study group. After 6 months follow up the tamponade was removed in all eyes. Results: The safety of AS SiO could be demonstrated: the AS SiO was well tolerated and stayed clear during the study period of 6 months. The clinical examination revealed no signs of local or systemic adverse effects in the study eyes. The visual acuities were well matched before inclusion into the study and there was no evidence of significant differences during the follow up period and in final visual outcome between the two groups. The rate of redetachments defined as the primary outcome parameter was the same for both groups. Conclusions: Acetylsalicylic acid delivery by intravitreal silicone oil in the human eye was shown a safe method that may offer a delivery route for other antiproliferative agents into the posterior pole.

KW - Acetylsalicylic acid-silicone oil suspension

KW - Efficiency

KW - Proliferative vitreoretinopathie

KW - PVR

KW - Safety

UR - http://www.scopus.com/inward/record.url?scp=36148962851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36148962851&partnerID=8YFLogxK

U2 - 10.1007/s00717-007-0214-0

DO - 10.1007/s00717-007-0214-0

M3 - Article

AN - SCOPUS:36148962851

VL - 21

SP - 218

EP - 220

JO - Spektrum der Augenheilkunde

JF - Spektrum der Augenheilkunde

SN - 0930-4282

IS - 4

ER -