Acetylcholine modulates two types of presynaptic potassium channels in vertebrate motor nerve terminals

E. Hevron, Gavriel David, A. Arnon, Y. Yaari

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Using external microelectrodes to record local circuit currents from preterminal motor nerve axons, two distinct populations of potassium (K) channels were identified in frog motor nerve terminals: delayed rectifier and calcium-activated K channels. Both are sensitive to the transmitter acetylcholine (ACh) which, when externally applied, blocks them in concentrations in the millimolar range. As this action also is not prevented by nicotinic and muscarinic antagonists, it probably is not mediated by classical cholinergic receptors. This cholinergic sensitivity of presynaptic K channels may account for the hyperexcitability of motor nerve terminals manifested when ACh accumulates in the junctional cleft.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalNeuroscience Letters
Volume72
Issue number1
DOIs
StatePublished - Dec 3 1986
Externally publishedYes

Fingerprint

Potassium Channels
Acetylcholine
Vertebrates
Nicotinic Antagonists
Calcium-Activated Potassium Channels
Muscarinic Antagonists
Microelectrodes
Cholinergic Receptors
Anura
Cholinergic Agents
Axons
Population

Keywords

  • Acetylcholine
  • Calcium-activated
  • Delayed rectifier
  • Frog
  • Motor nerve terminal
  • Potassium channel
  • Quaternary ammonium

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Acetylcholine modulates two types of presynaptic potassium channels in vertebrate motor nerve terminals. / Hevron, E.; David, Gavriel; Arnon, A.; Yaari, Y.

In: Neuroscience Letters, Vol. 72, No. 1, 03.12.1986, p. 87-92.

Research output: Contribution to journalArticle

Hevron, E. ; David, Gavriel ; Arnon, A. ; Yaari, Y. / Acetylcholine modulates two types of presynaptic potassium channels in vertebrate motor nerve terminals. In: Neuroscience Letters. 1986 ; Vol. 72, No. 1. pp. 87-92.
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