Accurate 3D source localization of focal epileptic foci using interictal EEG spikes

Mercedes Cabrerizo, Mohammed Goryawala, Prasanna Jayakar, Armando Barreto, Sakhrat Khizroev, Malek Adjouadi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

The goal of any surgery is the patient's complete recovery with maximum relief and minimal adverse effects. This goal is less complicated when epilepsy is predicated on tumor location revealed through standard imaging studies, in which case noninvasive post surgical studies can relate the 3D source with the area of the tumor that was removed. Success is more difficult, however, in non-lesional cases, where the characteristics of the epilepsy event are more difficult to define. This challenge reinforces the need for accurate 3D source localization to guarantee success of the first surgical intervention. Through this major undertaking which integrates recording modalities in time and space, clinicians and surgeons become more confident at prescribing a resection, especially when markers for the epileptogenic area and related brain functional assessments are consistent with the area thought to be the cause of the diagnosed neurological problem. This study evaluates the utility of 3D localization of interictal spike activity on the electroencephalographs (EEG) superimposed on magnetic resonance imagery (MRI) in a pediatric population. The results show a 99% concordance between EEG source localization and the suggested epileptogenic zone.

Original languageEnglish (US)
Title of host publication2011 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2011
DOIs
StatePublished - 2011
Event2011 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2011 - Brooklyn, NY, United States
Duration: Dec 10 2011Dec 10 2011

Publication series

Name2011 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2011

Conference

Conference2011 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2011
Country/TerritoryUnited States
CityBrooklyn, NY
Period12/10/1112/10/11

Keywords

  • 3-D source localization
  • epileptic focus
  • interictal spikes

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Medicine(all)

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