Accuracy of the ABC/2 Score for Intracerebral Hemorrhage: Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR III

Alastair J S Webb, Natalie L. Ullman, Tim C. Morgan, John Muschelli, Joshua Kornbluth, Issam A. Awad, Stephen Mayo, Michael Rosenblum, Wendy Ziai, Mario Zuccarrello, Francois Aldrich, Sayona John, Sagi Harnof, George Lopez, William C. Broaddus, Christine Wijman, Paul Vespa, Ross Bullock, Stephen J. Haines, Salvador Cruz-FloresStan Tuhrim, Michael D. Hill, Raj Narayan, Daniel F. Hanley

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background and Purpose - The ABC/2 score estimates intracerebral hemorrhage (ICH) volume, yet validations have been limited by small samples and inappropriate outcome measures. We determined accuracy of the ABC/2 score calculated at a specialized reading center (RC-ABC) or local site (site-ABC) versus the reference-standard computed tomography-based planimetry (CTP). Methods - In Minimally Invasive Surgery Plus Recombinant Tissue-Type Plasminogen Activator for Intracerebral Hemorrhage Evacuation-II (MISTIE-II), Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR-IVH) and CLEAR-III trials. ICH volume was prospectively calculated by CTP, RC-ABC, and site-ABC. Agreement between CTP and ABC/2 was defined as an absolute difference up to 5 mL and relative difference within 20%. Determinants of ABC/2 accuracy were assessed by logistic regression. Results - In 4369 scans from 507 patients, CTP was more strongly correlated with RC-ABC (r<sup>2</sup>=0.93) than with site-ABC (r<sup>2</sup>=0.87). Although RC-ABC overestimated CTP-based volume on average (RC-ABC, 15.2 cm<sup>3</sup>; CTP, 12.7 cm3), agreement was reasonable when categorized into mild, moderate, and severe ICH (κ=0.75; P<0.001). This was consistent with overestimation of ICH volume in 6 of 8 previous studies. Agreement with CTP was greater for RC-ABC (84% within 5 mL; 48% of scans within 20%) than for site-ABC (81% within 5 mL; 41% within 20%). RC-ABC had moderate accuracy for detecting ≥5 mL change in CTP volume between consecutive scans (sensitivity, 0.76; specificity, 0.86) and was more accurate with smaller ICH, thalamic hemorrhage, and homogeneous clots. Conclusions - ABC/2 scores at local or central sites are sufficiently accurate to categorize ICH volume and assess eligibility for the CLEAR-III and MISTIE III studies and moderately accurate for change in ICH volume. However, accuracy decreases with large, irregular, or lobar clots. Clinical Trial Registration - URL: http://www.clinicaltrials.gov. Unique identifier: MISTIE-II NCT00224770; CLEAR-III NCT00784134.

Original languageEnglish (US)
Pages (from-to)2470-2476
Number of pages7
JournalStroke
Volume46
Issue number9
DOIs
StatePublished - Sep 28 2015
Externally publishedYes

Fingerprint

Cerebral Hemorrhage
Tomography
Hemorrhage
Minimally Invasive Surgical Procedures
Tissue Plasminogen Activator
Reading
Logistic Models
Outcome Assessment (Health Care)
Clinical Trials
Sensitivity and Specificity

Keywords

  • cerebral hemorrhage
  • controlled clinical trials, randomized
  • review, systematic
  • sensitivity and specificity
  • tissue-type plasminogen activator

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Webb, A. J. S., Ullman, N. L., Morgan, T. C., Muschelli, J., Kornbluth, J., Awad, I. A., ... Hanley, D. F. (2015). Accuracy of the ABC/2 Score for Intracerebral Hemorrhage: Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR III. Stroke, 46(9), 2470-2476. https://doi.org/10.1161/STROKEAHA.114.007343

Accuracy of the ABC/2 Score for Intracerebral Hemorrhage : Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR III. / Webb, Alastair J S; Ullman, Natalie L.; Morgan, Tim C.; Muschelli, John; Kornbluth, Joshua; Awad, Issam A.; Mayo, Stephen; Rosenblum, Michael; Ziai, Wendy; Zuccarrello, Mario; Aldrich, Francois; John, Sayona; Harnof, Sagi; Lopez, George; Broaddus, William C.; Wijman, Christine; Vespa, Paul; Bullock, Ross; Haines, Stephen J.; Cruz-Flores, Salvador; Tuhrim, Stan; Hill, Michael D.; Narayan, Raj; Hanley, Daniel F.

In: Stroke, Vol. 46, No. 9, 28.09.2015, p. 2470-2476.

Research output: Contribution to journalArticle

Webb, AJS, Ullman, NL, Morgan, TC, Muschelli, J, Kornbluth, J, Awad, IA, Mayo, S, Rosenblum, M, Ziai, W, Zuccarrello, M, Aldrich, F, John, S, Harnof, S, Lopez, G, Broaddus, WC, Wijman, C, Vespa, P, Bullock, R, Haines, SJ, Cruz-Flores, S, Tuhrim, S, Hill, MD, Narayan, R & Hanley, DF 2015, 'Accuracy of the ABC/2 Score for Intracerebral Hemorrhage: Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR III', Stroke, vol. 46, no. 9, pp. 2470-2476. https://doi.org/10.1161/STROKEAHA.114.007343
Webb, Alastair J S ; Ullman, Natalie L. ; Morgan, Tim C. ; Muschelli, John ; Kornbluth, Joshua ; Awad, Issam A. ; Mayo, Stephen ; Rosenblum, Michael ; Ziai, Wendy ; Zuccarrello, Mario ; Aldrich, Francois ; John, Sayona ; Harnof, Sagi ; Lopez, George ; Broaddus, William C. ; Wijman, Christine ; Vespa, Paul ; Bullock, Ross ; Haines, Stephen J. ; Cruz-Flores, Salvador ; Tuhrim, Stan ; Hill, Michael D. ; Narayan, Raj ; Hanley, Daniel F. / Accuracy of the ABC/2 Score for Intracerebral Hemorrhage : Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR III. In: Stroke. 2015 ; Vol. 46, No. 9. pp. 2470-2476.
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abstract = "Background and Purpose - The ABC/2 score estimates intracerebral hemorrhage (ICH) volume, yet validations have been limited by small samples and inappropriate outcome measures. We determined accuracy of the ABC/2 score calculated at a specialized reading center (RC-ABC) or local site (site-ABC) versus the reference-standard computed tomography-based planimetry (CTP). Methods - In Minimally Invasive Surgery Plus Recombinant Tissue-Type Plasminogen Activator for Intracerebral Hemorrhage Evacuation-II (MISTIE-II), Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR-IVH) and CLEAR-III trials. ICH volume was prospectively calculated by CTP, RC-ABC, and site-ABC. Agreement between CTP and ABC/2 was defined as an absolute difference up to 5 mL and relative difference within 20{\%}. Determinants of ABC/2 accuracy were assessed by logistic regression. Results - In 4369 scans from 507 patients, CTP was more strongly correlated with RC-ABC (r2=0.93) than with site-ABC (r2=0.87). Although RC-ABC overestimated CTP-based volume on average (RC-ABC, 15.2 cm3; CTP, 12.7 cm3), agreement was reasonable when categorized into mild, moderate, and severe ICH (κ=0.75; P<0.001). This was consistent with overestimation of ICH volume in 6 of 8 previous studies. Agreement with CTP was greater for RC-ABC (84{\%} within 5 mL; 48{\%} of scans within 20{\%}) than for site-ABC (81{\%} within 5 mL; 41{\%} within 20{\%}). RC-ABC had moderate accuracy for detecting ≥5 mL change in CTP volume between consecutive scans (sensitivity, 0.76; specificity, 0.86) and was more accurate with smaller ICH, thalamic hemorrhage, and homogeneous clots. Conclusions - ABC/2 scores at local or central sites are sufficiently accurate to categorize ICH volume and assess eligibility for the CLEAR-III and MISTIE III studies and moderately accurate for change in ICH volume. However, accuracy decreases with large, irregular, or lobar clots. Clinical Trial Registration - URL: http://www.clinicaltrials.gov. Unique identifier: MISTIE-II NCT00224770; CLEAR-III NCT00784134.",
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TY - JOUR

T1 - Accuracy of the ABC/2 Score for Intracerebral Hemorrhage

T2 - Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR III

AU - Webb, Alastair J S

AU - Ullman, Natalie L.

AU - Morgan, Tim C.

AU - Muschelli, John

AU - Kornbluth, Joshua

AU - Awad, Issam A.

AU - Mayo, Stephen

AU - Rosenblum, Michael

AU - Ziai, Wendy

AU - Zuccarrello, Mario

AU - Aldrich, Francois

AU - John, Sayona

AU - Harnof, Sagi

AU - Lopez, George

AU - Broaddus, William C.

AU - Wijman, Christine

AU - Vespa, Paul

AU - Bullock, Ross

AU - Haines, Stephen J.

AU - Cruz-Flores, Salvador

AU - Tuhrim, Stan

AU - Hill, Michael D.

AU - Narayan, Raj

AU - Hanley, Daniel F.

PY - 2015/9/28

Y1 - 2015/9/28

N2 - Background and Purpose - The ABC/2 score estimates intracerebral hemorrhage (ICH) volume, yet validations have been limited by small samples and inappropriate outcome measures. We determined accuracy of the ABC/2 score calculated at a specialized reading center (RC-ABC) or local site (site-ABC) versus the reference-standard computed tomography-based planimetry (CTP). Methods - In Minimally Invasive Surgery Plus Recombinant Tissue-Type Plasminogen Activator for Intracerebral Hemorrhage Evacuation-II (MISTIE-II), Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR-IVH) and CLEAR-III trials. ICH volume was prospectively calculated by CTP, RC-ABC, and site-ABC. Agreement between CTP and ABC/2 was defined as an absolute difference up to 5 mL and relative difference within 20%. Determinants of ABC/2 accuracy were assessed by logistic regression. Results - In 4369 scans from 507 patients, CTP was more strongly correlated with RC-ABC (r2=0.93) than with site-ABC (r2=0.87). Although RC-ABC overestimated CTP-based volume on average (RC-ABC, 15.2 cm3; CTP, 12.7 cm3), agreement was reasonable when categorized into mild, moderate, and severe ICH (κ=0.75; P<0.001). This was consistent with overestimation of ICH volume in 6 of 8 previous studies. Agreement with CTP was greater for RC-ABC (84% within 5 mL; 48% of scans within 20%) than for site-ABC (81% within 5 mL; 41% within 20%). RC-ABC had moderate accuracy for detecting ≥5 mL change in CTP volume between consecutive scans (sensitivity, 0.76; specificity, 0.86) and was more accurate with smaller ICH, thalamic hemorrhage, and homogeneous clots. Conclusions - ABC/2 scores at local or central sites are sufficiently accurate to categorize ICH volume and assess eligibility for the CLEAR-III and MISTIE III studies and moderately accurate for change in ICH volume. However, accuracy decreases with large, irregular, or lobar clots. Clinical Trial Registration - URL: http://www.clinicaltrials.gov. Unique identifier: MISTIE-II NCT00224770; CLEAR-III NCT00784134.

AB - Background and Purpose - The ABC/2 score estimates intracerebral hemorrhage (ICH) volume, yet validations have been limited by small samples and inappropriate outcome measures. We determined accuracy of the ABC/2 score calculated at a specialized reading center (RC-ABC) or local site (site-ABC) versus the reference-standard computed tomography-based planimetry (CTP). Methods - In Minimally Invasive Surgery Plus Recombinant Tissue-Type Plasminogen Activator for Intracerebral Hemorrhage Evacuation-II (MISTIE-II), Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR-IVH) and CLEAR-III trials. ICH volume was prospectively calculated by CTP, RC-ABC, and site-ABC. Agreement between CTP and ABC/2 was defined as an absolute difference up to 5 mL and relative difference within 20%. Determinants of ABC/2 accuracy were assessed by logistic regression. Results - In 4369 scans from 507 patients, CTP was more strongly correlated with RC-ABC (r2=0.93) than with site-ABC (r2=0.87). Although RC-ABC overestimated CTP-based volume on average (RC-ABC, 15.2 cm3; CTP, 12.7 cm3), agreement was reasonable when categorized into mild, moderate, and severe ICH (κ=0.75; P<0.001). This was consistent with overestimation of ICH volume in 6 of 8 previous studies. Agreement with CTP was greater for RC-ABC (84% within 5 mL; 48% of scans within 20%) than for site-ABC (81% within 5 mL; 41% within 20%). RC-ABC had moderate accuracy for detecting ≥5 mL change in CTP volume between consecutive scans (sensitivity, 0.76; specificity, 0.86) and was more accurate with smaller ICH, thalamic hemorrhage, and homogeneous clots. Conclusions - ABC/2 scores at local or central sites are sufficiently accurate to categorize ICH volume and assess eligibility for the CLEAR-III and MISTIE III studies and moderately accurate for change in ICH volume. However, accuracy decreases with large, irregular, or lobar clots. Clinical Trial Registration - URL: http://www.clinicaltrials.gov. Unique identifier: MISTIE-II NCT00224770; CLEAR-III NCT00784134.

KW - cerebral hemorrhage

KW - controlled clinical trials, randomized

KW - review, systematic

KW - sensitivity and specificity

KW - tissue-type plasminogen activator

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